24,25) The gonadotropins also stimulate the production of gonadal hormones (androgens, estrogens, progestagens
, and inhibin) that then exert negative feedback on the hypothalamus and consequently inhibit GnRH secretion.
Epidemiologic aspects of exogenous progestagens
in relation to their role in pathogenesis of human breast cancer.
Chlebowski proposed, that the mechanism involves the angiogenic pathway, but other investigators have shown that under certain circumstances, progestagens
can stimulate stem cells by a paracrine RANKL (receptor-activated nuclear factor-kappaB ligand) mechanism.
2[alpha]] or by extending the cycle artificially with exogenous progesterone or more potent progestagens
(Evans and Maxwell, 1986; Jainudeen et al.
The use of systemic progestagens
although established in prevention of the endometrial neoplastic changes associated with oestrogen replacement therapy, unfortunately causes several unwanted side effects leading to poor compliance and discontinuation of the treatment.
Comparison of two progestagens
during out-of season breeding in a commercial ewe flock.
and antiprogestagens for pain associated with endometriosis.
In the Group 2 (G2, n=41) a protocol with intravaginal devices (DIV) of progestagens
was used: synchronization (day 0): estradiol benzoate (BE) 2 mg and 1 DIV of first use during 7 days; day 7: [PGF.
He is now renewing that call, and as he points out in a letter sent widely to British breeders today, and detailed on this page, there are already numerous artificial technologies - he names nine, including "[application of] Regu-Mate and other synthetic progestagens
to mimic dioestrus, suppress oestrous behaviour, induce follicular development and supplement the mare's own progesterone levels during pregnancy", and "immunisation with stallion white blood cells to prevent repeated early abortion in immunologically deficient mares" - used to help conception along.
Women with bothersome symptoms who haven't had a hysterectomy must take estrogen with a progestagen
to prevent estrogen-induced endometrial (uterine) cancer, and some progestagens
appear to increase the risk of breast cancer.
24) The effect of different Progestagens
as a component of CCHT on mammographic density is still debated.
for contraceptive use," Human Reproduction Update 12(2): 169-178.