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A small protein that binds to monomeric actin (thus becoming profilactin), preventing premature polymerization of actin. It also participates in the inhibition of one isoform of phospholipase C.
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Profilins are small proteins widely distributed in distantly related species.
Subjects sensitised only to cross-reacting plant profilins (Hev b 9) have a much reduced risk of clinical sensitivity.
For example, increased levels of IgG antibodies to vegetables and beans (including coffee beans) are sometimes associated with Lipid transfer proteins (LTP), lectins (polysaccharides), and/or profilins (actin binding proteins).
The plant proteins involved in OAS and PFS have been shown to belong to plant protein families, including those of profilins, pathogenesis-related proteins (PRs), and lipid transfer proteins.
Parietaria profilin shows only limited cross-reactivity with birch and grass profilins.
Cross-reactivities caused by defense-related proteins like plant profilins are responsible for the pollen-fruit syndrome and similarly the latex-fruit syndrome (Ganglberger, et al.
Plant profilins are responsible for a significant number of pollen-related allergies and are important pan-allergens.
papain-papaya, ficin-fig, Gly m 1 soybean); f) profilins (12-15 kd actin cytoskeleton-binding protein, Ara h 5 peanut, Gly m 3 soybean, Hev b 8 latex; g) peroxidases (induced by pathogens in plant defense); and h) lectins (agglutinins that bind specific sugars on glycoproteins: 31 kDa peanut).
3] Such cross-reactivity may occur in more than 50% of latex-allergic individuals, and is due to specific cross-reacting allergens such as profilins.