prodrug

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prodrug

 [pro´drug]
a compound that, on administration, must undergo chemical conversion by metabolic processes before becoming an active pharmacological agent; a precursor of a drug.

pro·drug

(prō'drŭg),
A class of drugs, the pharmacologic action of which results from conversion by metabolic processes within the body (biotransformation).

prodrug

/pro·drug/ (-drug) a compound that, on administration, must undergo chemical conversion by metabolic processes before becoming an active pharmacological agent; a precursor of a drug.

prodrug

(prō′drŭg′)
n.
Any of various drugs that are administered in an inactive form and converted into active form by normal metabolic processes.

prodrug

[prō′drug]
an inactive or partially active drug that is metabolically changed in the body to an active drug.

prodrug

Therapeutics A drug ingested in the inactive form which is transformed into an active form by in vivo metabolism

pro·drug

(prō'drŭg)
A class of drugs, the pharmacologic action of which results from conversion by metabolic processes within the body (biotransformation).

prodrug

A substance which, after metabolic action in the body, is coverted to an active drug.

prodrug

drug modified by biotransformation (i.e. metabolic processes) to achieve desired pharmacological action

pro·drug

(prō'drŭg)
A class of drugs, the pharmacologic action of which results from conversion by metabolic processes within the body.
References in periodicals archive ?
The patent extends coverage for GenSpera's series of PSA targeted prodrugs through 2026.
Thus, the ruthenium prodrug will be transformed inside cancer cells into a highly toxic molecule that will kill the cells.
Semafore's prodrug technology offers a way to enhance delivery of PI3K inhibitors selectively to the tissues of therapeutic interest while lessening the systemic exposure seen with non-prodrug approaches.
Metabasis says the HepDirect technology is a prodrug technology that specifically targets production of the biologically active form of certain drugs to the liver and preclinical studies have show that the use of the technology may result in higher active drug concentrations in the liver and decreased exposure to non-liver tissue.
The structure and tumor-selectivity of Super-Leu-Dox is based on a tumor-activated prodrug approach that is similar in concept to Diatos's TSP technology platform.
Prodrugs themselves may cross-react in immunoassays, thereby confounding pharmacokinetic data and clinical interpretation.
Cyterix was founded in April 2010 by a team of three scientific/clinical experts in the development of prodrugs and biochemistry of cytochrome P450 enzymes.
TransCon Treprostinil has been designed as an inert prodrug that enables a sustained release of unmodified treprostinil in circulation following a once-daily self-administered subcutaneous injection.
XenoPort is currently applying its technology to off-patent drugs to create patentable Transported Prodrugs with improved medicinal properties.
BB: GNSZ) announced that its patent application, entitled "Activation of Peptide Prodrugs by HK2," has been issued by the United States Patent and Trademark Office (USPTO) as US Patent 7,906,477.
These prodrugs aim to reduce the toxicity of treatment.
This new patent claims prodrugs, comprising a pharmacologically active compound covalently linked to an intracellular transporter by a bond which is preferentially cleaved by disease-associated supranormal enzyme activity.