prodrug

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prodrug

 [pro´drug]
a compound that, on administration, must undergo chemical conversion by metabolic processes before becoming an active pharmacological agent; a precursor of a drug.

pro·drug

(prō'drŭg),
A class of drugs, the pharmacologic action of which results from conversion by metabolic processes within the body (biotransformation).

prodrug

/pro·drug/ (-drug) a compound that, on administration, must undergo chemical conversion by metabolic processes before becoming an active pharmacological agent; a precursor of a drug.

prodrug

(prō′drŭg′)
n.
Any of various drugs that are administered in an inactive form and converted into active form by normal metabolic processes.

prodrug

[prō′drug]
an inactive or partially active drug that is metabolically changed in the body to an active drug.

prodrug

Therapeutics A drug ingested in the inactive form which is transformed into an active form by in vivo metabolism

pro·drug

(prō'drŭg)
A class of drugs, the pharmacologic action of which results from conversion by metabolic processes within the body (biotransformation).

prodrug

A substance which, after metabolic action in the body, is coverted to an active drug.

prodrug

drug modified by biotransformation (i.e. metabolic processes) to achieve desired pharmacological action

pro·drug

(prō'drŭg)
A class of drugs, the pharmacologic action of which results from conversion by metabolic processes within the body.
References in periodicals archive ?
M2 PHARMA-March 8, 2018-V ClinBio and Camargo Team to Develop Prodrug Technology Platform
In his research Sven Askes focussed on new prodrugs of the ruthenium-polypyridyl type.
The patent, which has been assigned the application number 14/385551, covers both pharmaceutical compositions containing the prodrugs of the glutamate modulating agent riluzole and methods of treating cancer, including melanoma, according to the company.
Polysaccharide based prodrugs of NSAIDs proved to be much effective and safer as compared to parent NSAIDs as it is evident from several studies [5-8].
Semafore's prodrug technology offers a way to enhance delivery of PI3K inhibitors selectively to the tissues of therapeutic interest while lessening the systemic exposure seen with non-prodrug approaches.
Metabasis says the HepDirect technology is a prodrug technology that specifically targets production of the biologically active form of certain drugs to the liver and preclinical studies have show that the use of the technology may result in higher active drug concentrations in the liver and decreased exposure to non-liver tissue.
The structure and tumor-selectivity of Super-Leu-Dox is based on a tumor-activated prodrug approach that is similar in concept to Diatos's TSP technology platform.
Prodrugs themselves may cross-react in immunoassays, thereby confounding pharmacokinetic data and clinical interpretation.
The company's goal is to discover and develop multiple classes of small molecule oncology prodrugs with a superior safety and efficacy profile to classical cytotoxic and molecularly targeted agents.
M2 PHARMA-January 30, 2018-US FDA Grants Ensysce Biosciences Fast Track Designation for Abuse Deterrent Extended Release Oxycodone Prodrug
9,073,916, generically covers a structural class of EGFR tyrosine kinase inhibitor prodrugs, including tarloxotinib, and pharmaceutical compositions containing this structural class of prodrugs.
The HPC-Ibuprofen conjugates as macromolecular prodrugs were therefore synthesized employing homogenous and one pot reaction methodology using p-toluenesulfonyl chloride.