probucol


Also found in: Dictionary, Wikipedia.
Related to probucol: Lorelco

probucol

 [pro´bu-kol]
a bis-phenol compound used as an anticholesteremic; taken orally.

probucol

Lorelco® Cardiology A hypocholesterolemic with antioxidant activity, that ↓ restenosis after balloon angioplasty. See Balloon angioplasty.

probucol

(prō′bū-kōl)
An antihypercholesteremic drug.

probucol (prōbyəkol´),

n brand names: Bifenabid, Lesterol, Lorelco, Lurselle, Superlipid;
drug class: antihyperlipidemic;
action: increases bile acid excretion, catabolism of low-density lipoprotein (LDL) cholesterol; may block oxidation of LDL cholesterol;
use: severe hypercholesterolemia when other treatment is unsuccessful.
References in periodicals archive ?
The most evident biochemical consequence of probucol treatment thus is a CETP-mediated reduction in HDL-C concentration, which some authors have also attributed in part to inhibition of ATP-binding cassette transporter 1 (ABCA1)-mediated HDL biogenesis.
Arteries are least likely to close up again on probucol alone, more likely on probucol plus antioxidants, and most likely on antioxidants or the placebo alone.
In a Canadian study of nonemergency patients, researchers tested the effectiveness of the antioxidant drug probucol in combating restenosis, the narrowing of blood vessels caused by scar tissue buildup after angioplasty.
Blood cholesterol-lowering agents--HMG CoA reductase inhibitors (or "stating"), nicotinic acid, bile acid sequestrants, fibric acid derivatives, and probucol.
While NCEP recommends cholestyramine, colestipol, gemfibrozil, lovastatin, niacin and probucol for these men, the cost-effectiveness of these drugs was not considered when the original drug recommendations were made," said John Eisenberg, M.
Protective effects of vitamin e and probucol against gentamicin-induced nephrotoxicity in rats.
Effect of probucol treatment on gene expression of VCAM-1, MCP-1 and M-CSF in the aortic wall of LDL receptor-deficient rabbits during early atherogenesis.
True (A) or false (B)--fill in only block A or B: Probucol commonly causes flushing and urticaria.
Probucol selectively increases oxidation of atherogenic lipoproteins in cholesterol-fed mice and in Watanabe heritable hyperlipidemic rabbits.
What's more, the arteries of people who took the antioxidant drug probucol were less likely to close up again than were those of people who took probucol plus the vitamins.