proband

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pro·band

(prō'band),
In human genetics, the patient or member of the family that brings a family under study.
Synonym(s): index case
[L. probo, to test, prove]

proband

/pro·band/ (pro´band) an affected person ascertained independently of relatives in a genetic study.

proband

(prō′bănd′, prō-bănd′)

proband

proband

Epidemiology A Pt who triggers study of other members of the family to identify the possible genetic factors involved in a given disease, condition, or characteristic. Cf Index case.

pro·band

(prō'band)
human genetics The patient or member of the family that brings a family under study.
[L. probo, to test, prove]

proband

The presenting patient of a group with an identical or similar disorder, especially the member of a family first found to have an inheritable disorder. Also known as propositus.

proband

an individual considered as the starting point for the study of a family for the inheritance of a particular condition.

proband

propositus.
References in periodicals archive ?
Increased risk of death from iron overload among 422 treated probands with HFE hemochromatosis and serum levels of ferritin greater than 1000 mug/L at diagnosis.
When the green square was visible the scientists repeatedly gave probands an unpleasant stimulus on the hand using a laser.
The current study is also the first to consider "the full spectrum of ACS without age restrictions on the proband or parent at time of vascular event," they stated.
9,10) The first study described six probands carrying different LDLR mutations out of a sample of 8 unrelated subjects.
We were able to recruit 47 relatives of mutation positive probands for analysis.
A small study by Edelson and Cantor found 100% of autistic probands had deficient liver detoxification ability, as assessed by the usual excretory tests, and 90% had high levels of many neurotoxic chemicals.
7) The ADOS, Autism Diagnostic Interview, and SCQ are established tools used to show that probands meet ICD-10 (54) and DSM-IV diagnostic criteria for autism.
In these families, the probands were the only individuals that had dental agenesis within their own family.
During the first stage, both the probands and their family members completed extensive interviews that allowed the investigators to determine whether participants met the diagnostic criteria for alcohol abuse or dependence.
Some studies show that female relatives of the fibromyalgia probands display higher rates of psychiatric disorders than do male relatives," said Dr.
Personality traits of the relatives of autistic probands.