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proarrhythmia

   Also found in: Wikipedia 0.02 sec.
proarrhythmia /pro·ar·rhyth·mia/ (pro″ah-rith´me-ah) cardiac arrhythmia that is either drug-induced or drug-aggravated.proarryth´mic
proarrhythmia
Cardiology A drug-related arrhythmia, seen in 4–6% of Pts treated for V tach or V fib, especially in Pts treated with digitalis & diuretics, ↓ left ventricular function, longer pretreatment Q-T intervals Pathogenesis Altered reentry substrate and early after depolarization. See Arrhythmia.


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2000) The potential for QT prolongation and proarrhythmia by non-antiarrhythmic drugs: Clinical and regulatory implications, European Heart Journal.
Drug-induced proarrhythmia and the use of QTc prolonging agents: Clues for clinicians.
Proarrhythmia is observed in patients treated with drugs that block the hERG channel, including quinidine, dofetilide, antihistamines, and antibiotics (Bednar et al.
 
 
 
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