proopiomelanocortin

(redirected from Pro-opiomelanocortin)

pro·o·pi·o·mel·a·no·cor·tin (POMC),

(prō-ō'pē-ō-mel'ă-nō-kōr'tin), [MIM*176830]
A large molecule found in the anterior and intermediate lobes of the pituitary gland, the hypothalamus, and other parts of the brain as well as in the lungs, gastrointestinal tract, and placenta; the precursor of ACTH, CLIP, β-LPH, γ-MSH, β-endorphin, and met-enkephalin.

POMC

A gene on chromosome 2p23 that encodes proopiomelanocortin, the melanocortin family of hormones, which include alpha-, beta- and gamma-melanocyte stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). The melanocortins bind to the melanocortin receptors, a group of five G protein-coupled receptors (MC1R to MC5R) which are involved in a wide range of physiological functions, including pigmentation, energy homeostasis, inflammation, immunomodulation, steroidogenesis and temperature control.

Molecular pathology
Defects of POMC are associated with susceptibility to obesity and proopiomelanocortin deficiency.

pro·o·pi·o·mel·a·no·cor·tin

(POMC) (prō-ō'pē-ō-mel'ă-nō-kōr'tin)
A large molecule found in the anterior and intermediate lobes of the pituitary gland, the hypothalamus, and other parts of the brain as well as in the lungs, gastrointestinal tract, and placenta.

proopiomelanocortin (POMC)

The prohormone from which ACTH, beta-lipotropin, and beta-ENDORPHIN are produced by cleavage. POMC is found most abundantly in the pituitary and hypothalamus, but also occurs in the sex glands and elsewhere.
References in periodicals archive ?
An expanding set of severe obesity genetic defects are now identified that involve genes in the pathway that are either upstream of MC4R-specifically, pro-opiomelanocortin (POMC) deficiency obesity, leptin receptor deficiency obesity, and likely Prader-Willi Syndrome (PWS)-or genes that are downstream of MC4R or that affect MC4R itself.
The gene's actions took place in pro-opiomelanocortin (Pomc) neurons in the hypothalamic region of the brain.
It has been suggested that presumed Silent ACTHoma precursor cells represent a distinct subtype of Pro-opiomelanocortin (POMC) producing cells residing mostly in the vestigial pars intermedia of the human pituitary.
In the obese rats alpha-MSH was low, despite an abundance of leptin and despite normal levels of gene expression both for its biochemical precursor protein called pro-opiomelanocortin (POMC) and for a key enzyme called PC2 that processes POMC in brain cells.
Chronic ethanol consumption impairs the circadian rhythm of pro-opiomelanocortin and period genes mRNA expression in the hypothalamus of the male rat.
corticotropin-releasing hormone (CRH), neuropeptide Y (NPY), agouti-related peptide (AgRP), pro-opiomelanocortin (POMC)) and fatty acid synthase (FAS).
In 2003, Action Pharma in-licensed Zealand Pharma A/S' (NASDAQ OMX Copenhagen: ZEAL) SIP[R] technology for use with pro-opiomelanocortin derivatives.
In 2003, Action Pharma in-licensed Zealand Pharma A/S' (NASDAQ OMX Copenhagen: ZEAL) SIP technology for use with pro-opiomelanocortin derivatives.
In a variety of experiments, the researchers found that the experimental drug activated a specific type of nicotine receptor, which in turn activated the subset of neurons in the hypothalamus, called pro-opiomelanocortin or POMC cells.
15,16) It is suggested that the increased [beta]-endorphin level induced by acupuncture affects the hypothalamic-pituitary-adrenal (HPA) axis by promoting the release of adrenocorticotropic hormone through stimulation of its precursor pro-opiomelanocortin synthesis.
Initiation of pro-opiomelanocortin mRNA from a normally quiescent promoter in a human small cell lung cancer cell line.
2) These studies focused on those cells that produce a signaling molecule called pro-opiomelanocortin (POMC), which is further modified to the endogenous opioid, p endorphin.