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An expanding set of severe obesity genetic defects are now identified that involve genes in the pathway that are either upstream of MC4R-specifically, pro-opiomelanocortin (POMC) deficiency obesity, leptin receptor deficiency obesity, and likely Prader-Willi Syndrome (PWS)-or genes that are downstream of MC4R or that affect MC4R itself.
The gene's actions took place in pro-opiomelanocortin (Pomc) neurons in the hypothalamic region of the brain.
It has been suggested that presumed Silent ACTHoma precursor cells represent a distinct subtype of Pro-opiomelanocortin (POMC) producing cells residing mostly in the vestigial pars intermedia of the human pituitary.
In the obese rats alpha-MSH was low, despite an abundance of leptin and despite normal levels of gene expression both for its biochemical precursor protein called pro-opiomelanocortin (POMC) and for a key enzyme called PC2 that processes POMC in brain cells.
Chronic ethanol consumption impairs the circadian rhythm of pro-opiomelanocortin and period genes mRNA expression in the hypothalamus of the male rat.
corticotropin-releasing hormone (CRH), neuropeptide Y (NPY), agouti-related peptide (AgRP), pro-opiomelanocortin (POMC)) and fatty acid synthase (FAS).
In 2003, Action Pharma in-licensed Zealand Pharma A/S' (NASDAQ OMX Copenhagen: ZEAL) SIP[R] technology for use with pro-opiomelanocortin derivatives.
In 2003, Action Pharma in-licensed Zealand Pharma A/S' (NASDAQ OMX Copenhagen: ZEAL) SIP technology for use with pro-opiomelanocortin derivatives.
In a variety of experiments, the researchers found that the experimental drug activated a specific type of nicotine receptor, which in turn activated the subset of neurons in the hypothalamus, called pro-opiomelanocortin or POMC cells.
15,16) It is suggested that the increased [beta]-endorphin level induced by acupuncture affects the hypothalamic-pituitary-adrenal (HPA) axis by promoting the release of adrenocorticotropic hormone through stimulation of its precursor pro-opiomelanocortin synthesis.
Initiation of pro-opiomelanocortin mRNA from a normally quiescent promoter in a human small cell lung cancer cell line.
2) These studies focused on those cells that produce a signaling molecule called pro-opiomelanocortin (POMC), which is further modified to the endogenous opioid, p endorphin.