proinsulin

(redirected from Pro-insulin)
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Related to Pro-insulin: preproinsulin

proinsulin

 [pro-in´soo͡-lin]
a precursor of insulin, having low biologic activity.

pro·in·su·lin

(prō-in'sŭ-lin),
A single-chain precursor of insulin.

proinsulin

/pro·in·su·lin/ (-in´su-lin) a precursor of insulin, having low biologic activity.

proinsulin

(prō-ĭn′sə-lĭn)
n.
A single-chain polypeptide that is the precursor of insulin, converted into insulin by enzymatic action.

proinsulin

[prō·in′s(y)əlin]
Etymology: L, pro + insula, island
a single-chain peptide molecule that is a precursor of insulin.

INS

A gene on chromosome 11p15.5 that encodes preproinsulin, which is cleaved post-translationally into the B- and A-chain peptides (which are covalently linked via two disulfide bonds to form insulin) and C-peptide. Insulin reduces blood glucose and increases cell permeability to monosaccharides, amino acids and fatty acids, and accelerates glycolysis, the pentose phosphate cycle and glycogen synthesis in the liver.

pro·in·su·lin

(prō-in'sŭ-lin)
A single-chain precursor of insulin.

proinsulin

a precursor of insulin, having low biological activity.
References in periodicals archive ?
We can also look at insulin, pro-insulin, HgbA1C, fasting glucose, and 2-hour postprandial and 30-minute insulin levels after a 75g glucose load.
Sembiosys Genetics, a Canadian company based in Calgary, Alberta, inserted human insulin genes into safflowers, causing them to make a compound called pro-insulin.
There was a decrease in insulin, pro-insulin and C-peptide levels.
Researchers initially concluded that C-peptide was merely a by-product of the excision of insulin from the larger pro-insulin molecule, but Dr.