Prinzmetal angina

Prinz·met·al an·gi·na

(prinz'met-ăl),
a form of angina pectoris, characterized by pain that is not precipitated by cardiac work, is of longer duration, is usually more severe, and is associated with unusual electrocardiographic manifestations including elevated ST segments in leads that usually show such elevation during acute coronary thrombosis occurring at night in bed.

Prinz·met·al an·gi·na

(prints'met-ăl an'ji-nă)
A form of angina pectoris that is characterized by pain that is not precipitated by cardiac work, is of longer duration, is usually more severe, and is associated with unusual electrocardiographic manifestations including elevated ST segments in leads that are ordinarily depressed in typical angina, and usually without reciprocal ST changes; occurring at night in bed in electrocardiographic leads in which ST segment depression occurs in typical angina. Treatment includes nitroglycerine or beta-blocker medications.
Synonym(s): angina inversa, variant angina pectoris, variant angina.

Prinzmetal angina

(prins'met?al)
[Myron Prinzmetal, U.S. cardiologist, 1908-1987]
Variant angina (under angina).

Prinzmetal,

Myron, U.S. cardiologist, 1908-1994.
Prinzmetal angina - a form of angina pectoris. Synonym(s): angina inversa; variant angina pectoris
Prinzmetal II syndrome - precordial anginal attacks. Synonym(s): angina pectoris variant
References in periodicals archive ?
Prinzmetal angina has a daily circadian rhythm with onset at rest, from midnight until early morning (Prinzmetal 1959) but it may be induced by exercise shortly after awakening.
The most common arrhythmia in patients with Prinzmetal angina is ventricular tachycardia, which initially occurs in 2/3 of the patients during anginal episodes, and 1/3 in resolution periods.
Although older people are more likely to develop Prinzmetal angina, smoking has a stronger effect in determining the occurrence of pathology in the young population.
The causes and mechanisms underlying the development of Prinzmetal angina are not fully understood; they are multifactorial, though:
Spontaneous ischemic episodes are often preceded by a decrease of the vagal activity, followed by an increase of catecholamines in the coronary level, to suggest that Prinzmetal angina is not necessarily induced by any vagal activity (Hung MJ 2014).
The research to determine genetic mutations or polymorphisms in the pathogenesis of Prinzmetal angina is inconsistent.
The diagnosis of Prinzmetal angina is complex and cannot be determined only by symptoms, electrocardiogram or stress testing.
Coronary angiography with provocative testing is the only reliable method for the diagnosis of Prinzmetal angina.
The early initiation of treatment in Prinzmetal angina is important in preventing complications such as myocardial infarction, arrhythmias or sudden death.
Both binedipine and amlodipine turned out to have very good results in the treatment of Prinzmetal angina (Kusama et al 2011).
Combinations of various classes of drugs like calcium channel blockers, nitrates and/or Nicorandil are necessary in patients with Prinzmetal angina resistant to initial pharmacological treatments.
Rajesh Kumar suffered an attack of Prinzmetal angina and collapsed and died in the garage of his home last December.