PRINCE (redirected from Prevention of Radiocontrast Induced Nephropathy Clinical Evaluation)

PRINCE

(1) Pravastatin Inflammation/CRP Evaluation. A trial which tested the effect of pravastatin on inflammation as evidenced by a reduction in C-reactive protein (CRP) levels
Conclusion Primary prevention arm: CRP decreased 14% with pravastatin and increased 3% with placebo (p < 0.001)
Secondary prevention arm: CRP decreased by 13%. Change in CRP was largely independent of pravastatin-induced changes in LDL-cholesterol
(2) Prevention of Radiocontrast Induced Nephropathy Clinical Evaluation. A prospective randomized trial of prevention measures in patients at high risk for contrast nephropathy, which tested the hypothesis that forced diuresis with maintenance of intravascular volume after contrast exposure reduces the incidence of contrast-induced renal injury
Conclusion Forced diuresis resulted in a higher urine flow rate over 24 h after contrast exposure (163 ml/h vs. 122.6 ml/h; p = 0.001). The incidence of renal failure in the post-procedure period was lower in patients with urine flow rate > 150 ml/h (p = 0.03)