Premarin


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Related to Premarin: Provera

estrogens, conjugated

C.E.S. (CA), Congest (CA), Premarin, Premarin Intravenous

Pharmacologic class: Estrogen

Therapeutic class: Replacement hormone, antineoplastic, antiosteoporotic

Pregnancy risk category X

Action

Bind to nuclear receptors in responsive tissues (such as female genital organs, breasts, and pituitary gland), enhancing DNA, RNA, and protein synthesis. In androgen-dependent prostate cancer, compete for androgen receptor sites, inhibiting androgen activity. Also decrease pituitary release of follicle-stimulating and luteinizing hormones.

Availability

Powder for injection: 25 mg/5 ml

Tablets: 0.3 mg, 0.625 mg, 0.9 mg, 1.25 mg

Vaginal cream: 0.625 mg/g

Indications and dosages

Ovariectomy; primary ovarian failure

Adults: 1.25 mg P.O. daily continuously or in cycles of 3 weeks on and 1 week off

Osteoporosis and menopausal symptoms

Adults: 0.3 to 1.25 mg P.O. daily continuously or in cycles of 3 weeks on and 1 week off

Female hypogonadism

Adults: 0.3 to 0.625 mg P.O. daily, given in cycles of 3 weeks on and 1 week off

Inoperable breast cancer in men and postmenopausal women

Adults: 10 mg P.O. t.i.d. for 3 months or more

Inoperable prostate carcinoma

Adults: 1.25 to 2.5 mg P.O. t.i.d.

Uterine bleeding caused by hormonal imbalance

Adults: 25 mg I.M. or I.V., repeated in 6 to 12 hours if necessary

Atrophic vaginitis, kraurosis vulvae

Adults: 0.5 to 2 g (vaginal cream) intravaginally daily in cycles of 3 weeks on and 1 week off

Moderate to severe dyspareunia

Adults: 0.5 g (vaginal cream) intravaginally daily in cycles of 3 weeks on and 1 week off

Contraindications

• Hypersensitivity to drug or its components
• Thromboembolic disease (current or previous)
• Undiagnosed vaginal bleeding
• Breast or reproductive system cancer (except metastatic disease)
• Estrogen-dependent neoplasms
• Pregnancy

Precautions

Use cautiously in:
• cardiovascular disease, severe hepatic or renal disease, asthma, bone disease, migraine, seizures, breast disease
• family history of breast or genital tract cancer
• breastfeeding patients.

Administration

• Know that drug is compatible with dextrose 5% in water and normal saline solution.

Adverse reactions

CNS: headache, dizziness, lethargy, depression, asthenia, paresthesia, syncope, cerebrovascular accident (CVA), seizures

CV: hypertension, chest pain, myocardial infarction (MI), thromboembolism

EENT: contact lens intolerance, worsening of myopia or astigmatism, otitis media, sinusitis, rhinitis, pharyngitis

GI: nausea, vomiting, diarrhea, abdominal cramps, bloating, enlarged abdomen, dyspepsia, flatulence, gastritis, gastroenteritis, hemorrhoids, colitis, gallbladder disease, anorexia, pancreatitis

GU: urinary incontinence, dysuria, urinary tract infection, amenorrhea, dysmenorrhea, endometrial hyperplasia, vaginal candidiasis, leukorrhea, vaginal hemorrhage, genital eruptions, gynecomastia, breast tenderness, breast enlargement or secretion, reduced libido, erectile dysfunction, testicular atrophy, increased risk of breast cancer, endometrial cancer, hemolytic uremic syndrome

Hepatic: cholestatic jaundice, hepatic adenoma

Metabolic: hyperglycemia, hypercalcemia, sodium and fluid retention, reduced carbohydrate tolerance

Musculoskeletal: leg cramps, back pain, skeletal pain

Respiratory: upper respiratory tract infection, bronchitis, pulmonary embolism

Skin: acne, oily skin, pigmentation changes, urticaria, pruritus, erythema nodosum, hemorrhagic eruption, skin hypertrophy, hirsutism, alopecia, erythema multiforme

Other: edema, weight changes, increased appetite, hypersensitivity reaction, angioedema

Interactions

Drug-drug.Corticosteroids: enhanced corticosteroid effects

CYP450 inducers (such as barbiturates, rifampin): decreased estrogen efficacy Hypoglycemics, warfarin: altered requirement for these drugs

Phenytoin: loss of seizure control

Tamoxifen: interference with tamoxifen effects

Tricyclic antidepressants: reduced antidepressant effects

Drug-diagnostic tests.Antithrombin III, folate, low-density lipoproteins, pyridoxine, total cholesterol, urine pregnanediol: decreased values

Cortisol; factors VII, VIII, IX, and X; glucose; high-density lipoproteins; phospholipids; prolactin; prothrombin; sodium; triglycerides: increased values

Metyrapone test: false decrease

Thyroid function tests: false interpretation

Drug-food.Caffeine: increased caffeine blood level

Drug-herbs.Black cohosh: increased risk of adverse reactions

Red clover: interference with estrogen effects

Saw palmetto: antiestrogenic effects St. John's wort: decreased drug blood level and effects

Drug-behaviors.Smoking: increased risk of adverse cardiovascular reactions

Patient monitoring

• Monitor liver function test results and assess abdomen for enlarged liver.
• Evaluate patient for breast tenderness and swelling. As needed, give analgesics and apply cool compresses.
• Monitor fluid intake and output, and weigh patient daily.

Know that drug increases risk of thromboembolism, CVA, and MI.
• Be aware that exogenous estrogens may induce or exacerbate symptoms of angioedema, particularly in women with hereditary angioedema.
• Check serum phosphatase level in patients with prostate cancer.
• Monitor calcium, glucose, and folic acid levels.
• Evaluate bone density annually.

Patient teaching

Teach patient to recognize and report signs and symptoms of thromboembolism.

Caution patient not to take drug if she is or plans to become pregnant.
• Tell patient to report breakthrough vaginal bleeding.
• Recommend that patient have routine breast examinations.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, foods, herbs, and behaviors mentioned above.

Premarin

(prĕm′ə-rĭn′)
A trademark for a drug preparation of conjugated estrogens.

Premarin

a trademark for conjugated estrogens.

Premarin®

Gynecology An estrogen conjugate obtained from pregnant horse mare urine commonly used as a hormone-replacement in postmenopausal ♀, to relieve the Sx of menopause–eg, hot flashes, osteoporosis, vaginal atrophy, etc Adverse effects Dizziness, lightheadedness, stomach upset, bloating or nausea, severe depression, calf pain, sudden severe headache, chest pain, SOB, lumps in breast, weakness or tingling in the arms or legs, dysmenorrhea

Premarin

A brand name for a preparation of conjugated oestrogens. The name is said to derive from the source-pregnant mare's urine.
References in periodicals archive ?
Her first foray into saving the Premarin mares came when she joined the nonprofit Ark Watch Foundation, an animal welfare group founded in California by Celine Myers and among the first to take on the plight of the Premarin mares.
To be included in the Class, consumers must also not be claiming any personal injury from the use of Prempro, Premarin, and/or Premphase.
Jonathan Wright points out that Premarin contains a minimal amount of estradiol and primarily contains conjugated equine estrogens, which are not natural to the human female.
If true, it coordinates with Wyeth's mishandling of a legal procedure in December for challenging property taxes on its Rouses Point plant near Plattsburgh that is now closing because of the drop in Premarin sales.
All your doctor needs to know is that you're happy with Premarin and would like to continue using the cream.
The FDA has also modified the approved indications for Premarin and other related products to clarify that these drugs should be used only when the benefits clearly outweigh risks.
The estrogen replacement therapy drug Premarin comes from pregnant mare urine (PMU).
A week later, Wyeth presented the society with a $250,000 check at a special event celebrating the 60th anniversary of Premarin, the company's other HRT drug.
Premarin and other estrogens made from horse urine have been shown in studies to protect against osteoporosis and heart disease.
When combined with Premarin, the clinical benefit of Premarin was maintained, while endometrial stimulation was inhibited, providing the first progestin-free therapy for hormone replacement and osteoporosis.
There exists a clinical preparation of conjugated estrogens that does come from pregnant mares' urine, Premarin.