preimplantation genetic diagnosis

(redirected from Pregenetic screening)
Also found in: Encyclopedia.

preimplantation genetic diagnosis (PGD)

in assisted reproductive technology, the determination of chromosomal abnormalities in the embryo before it is transferred to the uterus.

preimplantation genetic diagnosis

In assisted reproduction, the testing of a fertilized egg for heritable illnesses before the ovum is inserted into the female.
See also: diagnosis

preimplantation genetic diagnosis

The use of genetic analysis in the course of vitro fertilization to ensure that a baby does not possess a known genetic defect of either parent. After analysis of the embryos formed, only those free of defect are implanted in the mother's womb. A new method, developed in 2006, involves taking a single cell from the IVF embryo, amplifying the entire genome to provide many copies, and then comparing the chromosome containing the known family mutation with those of other family members by standard DNA fingerprinting techniques.