Prausnitz-Küstner reaction

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Prausnitz-Küstner reaction [prowz´nits kēst´ner]

an immediate hypersensitivity reaction produced in a nonatopic subject by intradermal injection of serum from an atopic subject followed 12 or more hours later by an injection of antigen. Formerly the standard method of demonstrating reaginic antibody, this test is no longer used because of the risk of transmitting serum hepatitis and because serum immunoglobulin E can now be measured by in vitro assays.

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