coli genome to create Vaccinobacter , a living factory of OMVs deprived of all unnecessary components but carrying the relevant immune potentiators
, 2) characterization and optimization of the immune stimulatory properties of OMVs, 3) development of novel methods to incorporate foreign antigens into Vaccinobacter-derived OMVs, 4) loading of OMVs with selected pathogen- and cancer-derived antigens and demonstration of their protective efficacy in appropriate animal models.
Synereca's novel potentiators
have shown the ability to significantly enhance the potency of Colistin, a last-line therapy against serious Gram-Negative bacterial infections, up to 500-fold against both susceptible and multi-drug resistant strains of Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobactericeae species including Klebsiella pneumonia and E.
The company has developed a number of potentiators
, or substances that may increase the activity of a particular protein.
In the alliance, AbbVie and Galapagos will develop potentiators
and correctors discovered by Galapagos and expand the range of molecules, with the aim to initiate Phase 1 clinical studies at the end of 2014.
The available research indicates that plant polyphenols, in particular those of tea (Camellia sinensis), are potent inhibitors of iron absorption from the GIT, and suggests that in combination with the avoidance of known potentiators
of iron uptake (meat, alcohol, fructose and vitamin C) consumption of tea polyphenols may be beneficial in individuals with HH and aid in the management of their condition.
Future Directions: Using Biotechnology to Discover New Sweeteners, Bitter Blockers & Sweetness Potentiators
suggests that chemopreventive agents could be used as potentiators
When standard adsorption studies are required, numerous technical procedures are employed nationwide, which include untreated RBCs without antigen-antibody reaction potentiators
, untreated RBCs with potentiators
such as low ionic strength solutions (LISS) or polyethylene glycol (PEG), enzymatic treatment of RBCs without potentiators
, and enzyme treated RBCs in conjunction with various potentiators
Both thickeners are nontoxic and non-irritating to eyes and skin and are not nitrosamine potentiators
The remaining chapters cover flavoring materials, flavoring material made by processing, artificial flavoring materials, flavor potentiators
, flavorists and flavor creation, flavor production, flavor applications, flavor legislation and religious dietary rules, and quality control.
Correctors and potentiators
are medicines in development that aim to treat the underlying cause of CF by improving the function of the defective protein known to cause the disease.
SeeNews) - Oct 17, 2013 -A Belgian biotechnology firm Galapagos (EBR:GLPG) said today it had developedA a series of novel potentiators
in its cystic fibrosis programme, with the data to be presented at theA North American Cystic Fibrosis Conference.