potassium-sparing diuretics

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po·tas·si·um-spar·ing di·u·ret·ics

(pǒ-tas'ē-ŭm spār'ing dī'yūr-et'iks)
Agents that retain potassium (e.g., triamterene and amiloride). They are used in the treatment of hypertension and in congestive heart failure.


powerful drugs, often termed ‘water tablets’, that control hypertension and peripheral oedema; action of some local anaesthetics is antagonized by concomitant use of some diuretics (see Table 1), e.g. aldosterone antagonists (e.g. spironolactone); carbonic anhydrase inhibitors, e.g. acetazolamide; loop diuretics, e.g. furosemide; osmotic diuretics, e.g. mannitol; potassium-sparing diuretics, e.g. amiloride, or in combination with other diuretics; thiazide diuretics, e.g. bendroflumethiazide
Table 1: Principal drug interactions of local anaesthetic agents and other medications
Local anaesthetic agent Proprietary name Principal drug interactionsEffect of interaction
Antiarrhythmic agents
Antibacterial agents
Ulcer-healing drugs
Increased myocardial depression
Increased risk of ventricular arrhythmias if lidocaine is given with quinpristin/dalfopristin
Increased risk of ventricular arrhythmias if lidocaine is given with any drug that prolongs the QT interval of the cardiac cycle
Plasma concentration of lidocaine increased by amprenavir, atazanavir and lopinavir
Increased myocardial depression
Increased risk of lidocaine toxicity when given with propranolol
The action of lidocaine is antagonized by the hypokalaemia caused by acetazolamide, loop diuretics or thiazide and related diuretics (i.e. a greater dose of lidocaine would be required to achieve anaesthesia)
Increased risk of ventricular arrhythmia if lidocaine is given with dolasetron
Plasma concentration of lidocaine increased when given with cimetidine; risk of lidocaine toxicity increased with cimetidine
Beta-blockersIncreased risk of bupivacaine toxicity when given with propranolol
Increased risk of myocardial depression if given with other antiarrhythmic agents
Antiarrhythmic agents
Antibacterial agents
Increased risk of myocardial depression if given with antiarrhythmic agents
Increased risk of methaemoglobinaemia if given with sulphonamide antibacterial agents
AntidepressantsMetabolism of ropivacaine is inhibited by fluvoxamine, thereby enhancing the risk of ropivacaine toxicity
Drug not listed in the British National Formulary
References in periodicals archive ?
Closer analysis showed the potassium-sparing diuretics accounted for all the risk reduction attributed to their drug class (aHR, 0.
In particular, special caution should be exercised in the use of potassium-sparing diuretics during concomitant therapy with ACE inhibitors, as this class of diuretics inherently increases serum potassium levels.
Potassium-sparing diuretics such as spironolactone (Aldactone) are useful both in people with heart failure and those with liver disease.
Potassium-sparing diuretics also are used in the management of hypertension.
5 mEq/L, then rule out eating too much fruit or other foods that are high in potassium; rule out concomitant use of NSAIDs, salt substitutes, and potassium-sparing diuretics such as triamterene, spironolactone, and eplerenone; and consider type 4 renal tubular acidosis.
Exclusion criteria included the use of potassium-sparing diuretics, a baseline serum creatinine over 2.
As with other drugs that block angiotensin II or its effects, concomitant use of potassium-sparing diuretics, potassium supplements, or salt substitutes containing potassium may lead to increases in serum potassium.
Potassium-sparing diuretics such as spironolactone (Aldactone) help the body retain potassium and also are more likely to be used to treat heart failure as well as be prescribed alongside the other two types of diuretics.
Elderly patients taking potassium-sparing diuretics had a 70% lower rate of developing Alzheimer's disease than did those who did not take antihypertensive drugs in a population-based study of dementing illnesses, reported Ara S.
Potassium-sparing diuretics are another class of agents which are frequently used to counteract the side effect of hypokalemia caused by other diuretics.
Potassium-sparing diuretics may not free the clinician from checking a potassium level, however.