posttranslational modifications


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posttranslational modifications

processes occurring after TRANSLATION of a POLYPEPTIDE, that are often needed to generate a fully functional polypeptide. Modifications include the introduction of a new functional group, specific PROTEOLYSIS, GLYCOSYLATION, protein phosphorylation (see PROTEIN KINASE) and METHYLATION.
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In turn, protein function is regulated by small molecular change known as posttranslational modifications, which cannot be detected in the DNA or RNA.
The glycome represents the totality of posttranslational modifications of secreted proteins by enzymatic glycosylation.
Objective: The overall objective of BioCapture is to develop novel robust assays for proteinaceous biomarkers associated with cancer and to develop innovative tools for assaying elusive cancer related posttranslational modifications in proteins.
sup][10] Analogous to other posttranslational modifications, ubiquitination is a reversible process counteracted by DUBs.
At the beginning a basic protein structure is translated from a DNA sequence followed by changes in the structure of basic protein called posttranslational modifications.
It was found that posttranslational modifications of these proteins by ROS/RNS are responsible for the development of CVD [41,42].
Four contributions focus on the genetic and molecular basis of episodic disorders, describing voltage-gated sodium channels, physiological disorders associated with ion channel membrane trafficking, the role of aberrant posttranslational modifications in acquired channelopathies, and episodic and electrical nervous system disorders caused by nonchannel genes.
His research interests include determining posttranslational modifications on EBOV glycoproteins and antiviral strategies for severe virus infections.
These changes are regulated by a number ofbiChemical prCesses, particularly posttranslational modifications (PTMs) such as phosphorylation, sulfation, acetylation, methylation, glycosylation etc.
Regulation of sirtuin function by posttranslational modifications.
While small molecules exist in single molecular compositions, even pure preparations of biopharmaceuticals contain multiple forms with different forms of the protein such as slightly different folding and different and multiple posttranslational modifications.
In addition, posttranslational modifications of the originator should be screened for.

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