RNA processing

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RNA processing

processes involved in the formation of mature, fully functional RNA species from primary RNA transcripts. For eukaryotic mRNA this may involve the removal of INTRONS (RNA splicing) and the addition of a cap at the 5′-end (See CAPPING (1)) and of a Poly(A) tail (see POLYADENYLATION). Generally little modification is made to prokaryotic mRNA; rRNA and tRNA in PROKARYOTES and EUKARYOTES are both modified. Both are cut out of large primary transcripts. For tRNA some of the bases are modified chemically. These processes occurring after TRANSCRIPTION are also called POSTTRANSCRIPTIONAL MODIFICATIONS.
References in periodicals archive ?
Ingenuity Pathway Analysis showed the following biological functions to be affected in the HPV+ samples: cancer, hematological disease, and RNA post-transcriptional modification.
Of all the RNAs, tRNA exhibits the largest number and most diverse modifications with cells from all kingdoms of life allocating a large portion of their genome to encoding enzymes involved in the post-transcriptional modification of nucleosides in tRNA [1].
Our comprehensive approach will answer how post-transcriptional modification control stem cell fate in normal tissues and might lead to the discovery of novel therapeutic strategies for neurological disorders in humans.
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are complexes of RNA and protein present in the nucleus during gene transcription and subsequent post-transcriptional modification of the newly synthesised RNA (pre-mRNA).
7) An alternative explanation for the low CK levels is that a generalised inflammatory state may result in post-transcriptional modification and enhanced degradation of CK.
Post-transcriptional modifications of proteins occur by all of the following EXCEPT

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