polymyxin

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Related to Polymyxin B: bacitracin

polymyxin

 [pol″e-mik´sin]
a generic term for antibiotics derived from various strains of Bacillus polymyxa, several closely related compounds being designated by letters.
polymyxin B a bacteriostatic and bactericidal antibiotic, effective mainly against gram-negative organisms. It is used as the sulfate salt, and is especially effective against Pseudomonas aeruginosa, which may cause septicemia, meningitis, urinary tract infections, and middle ear infections. Toxicity is low but there is sometimes damage to kidney and nerve cells. The route of administration is parenteral, oral, or topical to the ear or eye. Oral preparations are not used for systemic infections because the drug is poorly absorbed from the intestinal tract.

pol·y·myx·in

(pol'ē-mik'sin),
A mixture of antibiotic substances obtained from cultures of Bacillus polymyxa (B. serosporus), an organism found in water and soils and obtainable as a crystalline hydrochloride; all are polypeptides containing various amino acids and a branched-chain fatty acid, usually (+)-6-methyloctanoic acid. There are several polymyxins, (for example, designated A, B1, C, D, E, M, T), which are about equally effective against gram-negative bacteria, but which differ in toxicity, polymyxin E (colistin) and polymyxin B being the least toxic.
See also: colistimethate sodium.

polymyxin

/poly·myx·in/ (-mik´sin) generic term for antibiotics derived from Bacillus polymyxa; they are differentiated by affixing different letters of the alphabet.
polymyxin B  the least toxic of the polymyxins; its sulfate is used in the treatment of various gram-negative infections.

polymyxin

(pŏl′ē-mĭk′sĭn)
n.
Any of various mainly toxic antibiotics derived from strains of the soil bacterium Bacillus polymyxa and used to treat various infections with gram-negative bacteria.

pol·y·myx·in

(P) (pol'ē-mik'sin)
A mixture of antibiotic substances obtained from cultures of Bacillus polymyxa, an organism found in water and soils and obtainable as a crystalline hydrochloride.

pol·y·myx·in

(pol'ē-mik'sin)
A mixture of antibiotic substances obtained from cultures of Bacillus polymyxa (B. serosporus).

polymyxin (pol´ēmik´sin),

n an antibiotic substance derived from cultures of
B. polymyxa. Used topically, in troche form, in combination with bacitracin and neomycin in the treatment of various oral infections. Not used systemically; therefore sensitization is minimized. Systemic use may be attended by renal dysfunction and toxicity.

polymyxin

a generic term for antibiotics derived from various strains of Bacillus polymyxa, several closely related compounds being designated by letters.

polymyxin B
a bacteriostatic and bactericidal antibiotic, effective mainly against gram-negative organisms. It is used as the sulfate salt, and is especially effective against Pseudomonas aeruginosa and is also used against Klebsiella spp. It is used mostly in combinations with other antibiotics as a topical dressing including ophthalmic and aural preparations. It is not absorbed from the alimentary tract and is not recommended for systemic use because of its nephrotoxicity and neurotoxicity.
polymyxin E
References in periodicals archive ?
Polymyxin B resistance and biofilm formation in Vibrio cholerae are controlled by the response regulator CarR.
Initial recall notification of the Polymyxin B for Injection and Vecuronium Bromide for Injection lots listed above were sent to impacted wholesalers and distributors on August 2, 2011 by overnight courier and arranged for return of all recalled product.
Polymyxin B sulfate is an antibacterial drug used in the treatment of infections of the urinary tract, meninges and bloodstream caused by susceptible strains of Pseudomonas aeruginosa.
Researchers and physicians alike have been focusing on using combinations of colistin, polymyxin B, rifampin, and imipenem, although other drug combinations have been considered as well.
Key Words: antimicrobial drug resistance, neomycin, ofloxacin, otitis externa, polymyxin B
Polymyxin B was first isolated from a spore-bearing soil bacillus in 1947.
strains exhibiting reduced susceptibility to polymyxin B among 100 bloodstream isolates of Acinetobacter spp.
Food and Drug Administration (FDA) of its Abbreviated New Drug Application (ANDA) for Polymyxin B Sulfate for Injection, USP, 500,000 units/vial, the equivalent of Bedford Laboratories Polymyxin B Sulfate.
Polymyxin B Sulfate 10,000 IU + Bacitracin Zinc 500 IU per gram of ointment.
Its antipseudomonal activity is found in the neomycin and polymyxin B components.
AMEX:AKN) today announced that it has signed a commercial manufacturing supply agreement with X-Gen Pharmaceuticals for the product, Neomycin and Polymyxin B Sulfates Solution for Irrigation USP.