polymyxin

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Related to Polymixin: Polymyxin B, neomycin, Polymyxin b sulfate, Polymyxin E

polymyxin

 [pol″e-mik´sin]
a generic term for antibiotics derived from various strains of Bacillus polymyxa, several closely related compounds being designated by letters.
polymyxin B a bacteriostatic and bactericidal antibiotic, effective mainly against gram-negative organisms. It is used as the sulfate salt, and is especially effective against Pseudomonas aeruginosa, which may cause septicemia, meningitis, urinary tract infections, and middle ear infections. Toxicity is low but there is sometimes damage to kidney and nerve cells. The route of administration is parenteral, oral, or topical to the ear or eye. Oral preparations are not used for systemic infections because the drug is poorly absorbed from the intestinal tract.

pol·y·myx·in

(pol'ē-mik'sin),
A mixture of antibiotic substances obtained from cultures of Bacillus polymyxa (B. serosporus), an organism found in water and soils and obtainable as a crystalline hydrochloride; all are polypeptides containing various amino acids and a branched-chain fatty acid, usually (+)-6-methyloctanoic acid. There are several polymyxins, (for example, designated A, B1, C, D, E, M, T), which are about equally effective against gram-negative bacteria, but which differ in toxicity, polymyxin E (colistin) and polymyxin B being the least toxic.
See also: colistimethate sodium.

polymyxin

/poly·myx·in/ (-mik´sin) generic term for antibiotics derived from Bacillus polymyxa; they are differentiated by affixing different letters of the alphabet.
polymyxin B  the least toxic of the polymyxins; its sulfate is used in the treatment of various gram-negative infections.

polymyxin

(pŏl′ē-mĭk′sĭn)
n.
Any of various mainly toxic antibiotics derived from strains of the soil bacterium Bacillus polymyxa and used to treat various infections with gram-negative bacteria.

pol·y·myx·in

(P) (pol'ē-mik'sin)
A mixture of antibiotic substances obtained from cultures of Bacillus polymyxa, an organism found in water and soils and obtainable as a crystalline hydrochloride.

pol·y·myx·in

(pol'ē-mik'sin)
A mixture of antibiotic substances obtained from cultures of Bacillus polymyxa (B. serosporus).

polymyxin (pol´ēmik´sin),

n an antibiotic substance derived from cultures of
B. polymyxa. Used topically, in troche form, in combination with bacitracin and neomycin in the treatment of various oral infections. Not used systemically; therefore sensitization is minimized. Systemic use may be attended by renal dysfunction and toxicity.

polymyxin

a generic term for antibiotics derived from various strains of Bacillus polymyxa, several closely related compounds being designated by letters.

polymyxin B
a bacteriostatic and bactericidal antibiotic, effective mainly against gram-negative organisms. It is used as the sulfate salt, and is especially effective against Pseudomonas aeruginosa and is also used against Klebsiella spp. It is used mostly in combinations with other antibiotics as a topical dressing including ophthalmic and aural preparations. It is not absorbed from the alimentary tract and is not recommended for systemic use because of its nephrotoxicity and neurotoxicity.
polymyxin E
References in periodicals archive ?
We designed this new Gram negative plate to include the antimicrobics colistin and polymixin B at the request of drug-resistance researchers because of resurgence in the use of these 50-year-old antibiotics to treat multi-drug-resistant infections.
To this, the following antibiotics were added -carbenicillin (30 [micro]g/ml), polymixin B sulphate (30 [micro]g/ml), chloramphenicol (150 [micro]g/ml), and itraconazole (1 [micro]g/ml).
ulcerans strains may have different growth requirements or may be more sensitive to the antimicrobial agents in semisolid transport medium (PANTA: polymixin B, amphothericin B, nalidixic acid, trimethoprim, and azlocillin) than those from other geographic locations.
3% OP SOL Polymixin SULF/TMP SOL* Antidepressant Amitriptylin 100MG TAB Amitriptylin 10MG TAB Amitriptylin 25MG TAB Amitriptylin 50MG TAB Amitriptylin 75MG TAB Citalopram 20MG TAB Citalopram 40MG TAB Doxepin HCL 100MG CAP Doxepin HCL 10MG CAP Doxepin HCL 25MG CAP Doxepin HCL 50MG CAP Doxepin HCL 75MG CAP Fluoxetine 10 MG TAB* Fluoxetine 10MG CAP* Fluoxetine 20MG CAP Fluoxetine 40MG CAP Nortriptylin 10MG CAP Nortriptylin 25MG CAP Paroxetine 10MG TAB* Paroxetine 20MG TAB* Trazodone 100MG TAB Trazodone 150MG TAB Trazodone 50MG TAB Antifungal Fluconazole 150MG TAB Nystat/Triam CRE 15 Nystat/Triam CRE 30 Nystat/Triam OIN 15 Nystatin 100000U CRE 15 Nystatin 100000U CRE 30 Nystatin100000U OIN 15 Nystatin 100000U OIN 30 Antipsychotic Fluphenazine 1MG TAB Haloperidol 0.
The products include Bacitracin; Bacitracin Zinc and Polymixin B Sulfate; Gentamicin Sulfate, Neomycin and Polymyxin B Sulfates and Bacitracin Zinc; Neomycin and Polymyxin B Sulfates and Dexamethasone; Neomycin and Polymyxin B Sulfates, Bacitracin Zinc and Hydrocortisone Acetate as well Erythromycin Ophthalmic Ointments USP.
VIM]-positive isolates (49 of 64 [76%]) exhibited a multidrug-resistant phenotype including all the tested drugs (imipenem, meropenem, ceftazidime, piperacillin, aztreonam, amikacin, gentamicin, tobramycin, and ciprofloxacin), except polymixin B.
In the first quarter of 2008, APP received final FDA approval on four products and launched the following Polymixin B Sulfate, Caffeine Citrate Oral Solution, and Irinotecan Hydrochloride.
3% OP SOL Polymixin SULF/TMP SOL Antidepressant Amitriptylin 100MG TAB Amitriptylin 10MG TAB Amitriptylin 25MG TAB Amitriptylin 50MG TAB Amitriptylin 75MG TAB Citalopram 20MG TAB Citalopram 40MG TAB Doxepin HCL 100MG CAP Doxepin HCL 10MG CAP Doxepin HCL 25MG CAP Doxepin HCL 50MG CAP Doxepin HCL 75MG CAP Fluoxetine 10 MG TAB Fluoxetine 10MG CAP Fluoxetine 20MG CAP Fluoxetine 40MG CAP Nortriptylin 10MG CAP Nortriptylin 25MG CAP Paroxetine 10MG TAB Paroxetine 20MG TAB Trazodone 100MG TAB Trazodone 150MG TAB Trazodone 50MG TAB Antifungal Fluconazole 150MG TAB Nystat/Triam CRE 15 Nystat/Triam CRE 30 Nystat/Triam OIN 15 Nystatin 100000U CRE 15 Nystatin 100000U CRE 30 Nystatin100000U OIN 15 Nystatin 100000U OIN 30 Antipsychotic Fluphenazine 1MG TAB Haloperidol 0.