polyene

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Related to Polyenes: Azoles

polyene

 [pol´e-ēn]
1. a chemical compound with a carbon chain of four or more atoms and several conjugated double bonds.
2. any of a group of antibiotic antifungal agents with similar structure, such as amphotericin b, candicidin, or nystatin; they are produced by species of Streptomyces that damage cell membranes by forming complexes with sterols.

pol·y·ene

(pol'ē-ēn),
A chemical compound having a series of conjugated (alternating) double bonds; for example, the carotenoids.

polyene

/pol·y·ene/ (pol´e-ēn)
1. a chemical compound with a carbon chain of four or more atoms and several conjugated double bonds.
2. any of a group of antifungal antibiotics with such a structure (e.g., amphotericin and nystatin) produced by species of Streptomyces that damage cell membranes by forming complexes with sterols.

polyene

1 a chemical compound with a carbon chain of four or more atoms and several conjugated double bonds.
2 any of a group of antibiotic, antifungal agents with similar structure, such as Amphotericin B or Nystatin; they are produced by a species of Streptomyces that damage cell membranes by forming complexes with sterols.

polyene

chemical compound characterized by the presence of several conjugated double bonds.

polyene antibiotics
a group of agents, synthesized by Streptomyces spp., with antifungal activity; includes amphotericin B, nystatin and candicidin.
References in periodicals archive ?
An early example of what this process could lead to is Burke's work on one particular polyene compound, an extremely valuable but also highly toxic antifungal drug called amphotericin.
The report titled "Global Antifungal Therapeutics Market: Trends and Opportunities (2014-2019)" provides an in-depth analysis of global antifungal therapeutics market with focus on antifungal drug classes - Polyenes, Azoles, Echinocandins and Allylamines.
Polyenes bind directly to the unique fungal sterol ergosterol and compromise membrane function.
those that result from the reaction of polyenes with HCI.
DRE is the quantity which allows one to account for the effects of electron delocalization and thus serves as a measure of the stabilization of a polyenes molecular entity.
The polyenes cause the fungal cell to die by intercalating into ergosterol-containing membranes, the major sterol in fungal membrane, to form channels and destroy the proton gradient in the cell with leakage of cytoplasmic content (30,31).
As a class, the echinocandins possess a mechanism of action that is distinct from those of the polyenes, azoles, allylamines, or flucytosine.
The versatile and elegant use of palladium to mediate construction of polycyclic structures from acyclic polyenes was described by Larry Overman.
Reduction process of [alpha],[omega]-diphenyl polyenes.
Like the quinones, these polyenes have counterparts in natural photosynthesis molecules.