This anticipated patent, called Disinfectant with Quaternary Ammonium Polymers and Copolymers, covers the incorporation of the polycation
into the main chain of the urethane polymer.
Furthermore, the condensing agent must also possess the ability to protect ON from enzymatic degradation, be compatible with the nonviral delivery system, and resist displacement of the polycation
from the ON due to a biologically relevant protein (albumin, fibrinogen, serum, etc) until it has reached its target.
In a study presented yesterday, the Lipid Polycation
DNA delivery system was used to deliver E1A, a proprietary tumor inhibitor gene, systemically to mice transplanted with human head and neck tumors.
The formation of lateral aggregates of actin filaments in response to polycations
begins at a threshold concentration that varies strongly with the valence of the cation and increases with the ionic strength of the solution.
On adding the dye the conformation of the polycation
changes to a compact coil owing to dye binding, resulting from electrostatic interaction thus giving rise to metachromatic band.
The first component is a linear, cyclodextrin-containing polycation
that, when mixed with small interfering RNA (siRNA), binds to the anionic "backbone" of the siRNA.
2] contained a hemolyzer, an initiator consisting of a polycation
, and an arginine buffer (pH 8.
Indeed, viscometric behaviors are related to the chemical structure of the polycation
, to its size and charge density, but also to environment properties such as ionic strength, pH, and addition of other solvent or salts .
Before sample injection, the capillary was first rinsed with initiator solution (containing a polycation
, albumin, pH 4.
The films will be made by successively adsorbing polycations
and polyanions onto the electrodes.
Yermak IM, Davydova VN (2008) Interaction of bacterial lipopolysaccharides with host soluble proteins and polycations
have been shown to have orders of magnitude higher general biocompatibility than PEI .