polyadenylation

(redirected from Polyadenosine)
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pol·y·ad·e·nyl·a·tion

(pol'ē-ad'ĕ-nil-ā'shŭn),
1. The process of formation of poly(adenylic acid).
2. The covalent modification of a macromolecule (for example, mRNA) by the formation of a polyadenylyl moiety covalently linked to the macromolecule.

polyadenylation

The process by which a sequence of polyadenylic acids (adenosine ribonucleotides) is added to the end of a spliced RNA after its transcription from DNA, resulting in mature mRNA. This addition on the RNA molecule is sometimes referred to as a poly-A tail, and commonly contains several-hundred bases.

polyadenylation

addition of a sequence of ADENINE NUCLEOTIDES to the 3′-end of most eukaryotic RNA molecules, after their TRANSCRIPTION. The sequence is often called a.poly(A) tail.

polyadenylation

the addition of up to 250 adenylate residues to the 3′ end of eukaryotic mRNAs to form a so-called poly(A) tail. The primary transcript is cleaved by a specific endonuclease that recognizes the sequence AAUAAA which is also referred to as a polyadenylation signal sequence. The poly(A) tail protects the mRNA from digestion with nuclease and greatly increases the efficiency of translation.
References in periodicals archive ?
This domain can bind polyadenosine diphosphate-ribose regions and could play a role in the replication or transcription of virus RNA.
Protection by thymidine, an inhibitor of polyadenosine diphosphate ribosylation, of streptozotocin inhibition of insulin secretion.
Surveyed experts indicate that polyadenosine 5'-diphosphoribose polymerase (PARP) inhibition is the most exciting drug development strategy in this indication," said Decision Resources Analyst Marcus Hoyle.