PARP

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PARP

Poly(ADP-ribose) polymerase. Any of a group of enzymes (five have been identified—PARP1–5) whose prototypic member (PARP1) is encoded by PARP1 on chromosome 1q41-q42. PARP1 detects and repairs single strand breaks in chromosomal DNA, and plays a key role in initiating DNA repair. High levels of PARP1 are associated with increased apoptosis in response to genotoxic stress, and it may act downstream of the Raf-MEK-ERK pathway through direct interaction with ERK2 in the nucleus, repairing DNA damage. PARP inhibitors are being explored as therapies for cancer, diabetes, stroke and cardiovascular disease.
References in periodicals archive ?
Libberton continues: "In addition to the use of existing platinum-based chemotherapy, treatments such as anti-angiogenic treatments and Poly ADP Ribose Polymerase inhibitors are expected to have a positive impact on ovarian cancer survival in particular patient subsets.
The results of an Oregon Health and Science University Knight Cancer Institute study have prompted additional exploration into whether the patient population included in clinical trials for drugs that target the enzyme poly ADP ribose polymerase (PARP) should be expanded.
On September 4, 2013, AstraZeneca PLC (AstraZeneca) announced the enrollment of the first patient in the Phase III clinical programme for olaparib, an innovative oral poly ADP ribose polymerase (PARP) inhibitor being investigated for the treatment of BRCA mutated ovarian cancer.