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polyadenylation
(redirected from Poly A tail)

   Also found in: Encyclopedia, Wikipedia 0.01 sec.
polyadenylation
the addition of up to 250 adenylate residues to the 3′ end of eukaryotic mRNAs to form a so-called poly(A) tail. The primary transcript is cleaved by a specific endonuclease that recognizes the sequence AAUAAA which is also referred to as a polyadenylation signal sequence. The poly(A) tail protects the mRNA from digestion with nuclease and greatly increases the efficiency of translation.


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Baltimore should have asked himself why, after copying a protein-coded DNA sequence to a messenger RNA sequence and after the processing of this sequence, a poly A tail has to be attached to the "mature" messenger RNA as otherwise protein synthesis would not work.
1%) had dual polyadenylation signals an appropriate distance upstream (both within 35 bp) of the poly A tail.
After the copy is made, a string of up to 200 "A"-type nucleotides - a poly A tail - is added to its end (picture 2).
 
 
 
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