poloxamer

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poloxamer

 [pol-ok´sah-mer]
any of a series of nonionic surfactants, also used as emulsifiers, stabilizers, and food additives.

poloxamer

(pōl-oks'a-mĕr),
A surfactant derived from natural gas and oil.

poloxamer

/pol·ox·a·mer/ (pol-ok´sah-mer) any of a series of nonionic surfactants of the polyoxypropylene-polyoxyethylene copolymer type, used as surfactants, emulsifiers, stabilizers, and food additives.
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The Company is leveraging its MAST platform, derived from over two decades of clinical, nonclinical and manufacturing experience with purified and non-purified poloxamers, to develop vepoloxamer (also known as MST-188), its lead product candidate, for serious or life-threatening diseases and conditions typically characterized by impaired microvascular blood flow and damaged cell membranes.
The work we are doing with Mast is one example of our collaborations with pharmaceutical companies to develop high purity poloxamers for a variety of applications for the pharmaceutical and biotechnology value chains, said Daniele Piergentili, Head of Global Marketing and R&D, BASF Pharma Ingredients and Services.
However, poloxamers have shown to incorporate into the cellular membranes, particularly of the cancerous cells, affecting so the microviscosity of the cell membrane.
For example, poly-N-isopropylacrylamide becomes insoluble at about 37[degrees]C, hydroxypropyl cellulose separates at temperatures above about 40[degrees]C and poloxamers gel once the temperature reaches the lower critical solution temperature (LCST).
Our options for adjuvants in future vaccines also include proven cationic lipids such as DMRIE/DOPE, which has demonstrated excellent safety in our cancer studies; poloxamers, which have demonstrated both safety and utility as vaccine adjuvants; and of course, alum, which is commonly used as an adjuvant in conventional vaccines.
THE SOLUBILITY OF BENZOIC ACID IN POLOXAMERS HAVING A CONSTANT PERCENT OF THEIR MOLECULAR WEIGHT FROM POLYETHELENE OXIDE, J.
Previously, poloxamers including POE-POP have been successfully utilized as surface modifiers for improving the stability of latex particles [23] and as vehicles for transdermal drug delivery [24].
The preparation of multiple emulsions that can be facilitated by the use of thermogelling amphipathic block copolymers that are prepared by end-capping Poloxamers with poly (acrylic acid).
The Company is leveraging its MAST platform, derived from over two decades of clinical, nonclinical and manufacturing experience with purified and non-purified poloxamers, to develop vepoloxamer (MST-188), its lead product candidate, for serious or life-threatening diseases and conditions typically characterized by impaired microvascular blood flow and damaged cell membranes.
The panel considered final safety assessments for the alcohol denaured group and the poloxamers group, as well as amended final safety assessment for propyl gallate.
The Company is leveraging its molecular adhesion and sealant technology (MAST) platform, derived from over two decades of clinical, nonclinical and manufacturing experience with purified and non-purified poloxamers, to develop vepoloxamer (also known as MST-188), its lead product candidate, for serious or life-threatening diseases and conditions typically characterized by impaired microvascular blood flow and damaged cell membranes.