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an antineoplastic antibiotic produced by Streptomyces plicatus that binds to DNA and inhibits RNA synthesis; it is used for treatment of advanced testicular carcinoma; major side effects are thrombocytopenia and hemorrhagic diathesis that can be life-threatening. It also has an inhibiting effect on osteoclasts and is used to treat hypercalcemia and hypercalciuria caused by metastatic malignancy. Administered intravenously. Formerly called mithramycin.
plicamycin/pli·ca·my·cin/ (pli″kah-mi´sin) an antineoplastic antibiotic produced by Streptomyces plicatus; used in the treatment of advanced testicular carcinoma. It also has an inhibiting effect on osteoclasts and is used to treat hypercalcemia and hypercalciuria associated with malignancy.
an antineoplastic agent. Formerly called mithramycin.
indications It is prescribed primarily in the treatment of malignant tumors of the testis. It is also prescribed in the treatment of hypercalcemia and hypercalciuria associated with cancer.
contraindications Clotting disorders, thrombocytopenia, kidney or liver dysfunction, bone marrow depression, or known hypersensitivity to this drug prohibits its use.
adverse effects Among the more serious adverse effects are thrombocytopenia and clotting defects. Nausea and stomatitis commonly occur.
an antineoplastic antibiotic produced by Streptomyces argillaceus and S. tanashiensis; particularly effective in treating the hypercalcemia associated with canine lymphosarcoma. Called also mithramycin.