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Related to Plendil: Plavix, Felodipine, Amlodipine, Coversyl, Concor


Cardioplen (UK), Felotens (UK), Keloc (UK), Neofel (UK), Plendil, Renedil (CA), Vascalpha (UK)

Pharmacologic class: Calcium channel blocker

Therapeutic class: Antihypertensive, antianginal

Pregnancy risk category C


Impedes extracellular calcium ion movement across membranes of myocardial muscle cells, depressing myocardial contractility and impulse formation; slows impulse conduction velocity and dilates coronary arteries and peripheral arterioles. Net effect is reduced cardiac workload and lower blood pressure.


Tablets (extended-release): 2.5 mg, 5 mg, 10 mg

Indications and dosages


Adults: Initially, 5 mg P.O. daily. Depending on response, may decrease to 2.5 mg or increase to a maximum of 10 mg P.O. daily at 2-week intervals.

Dosage adjustment

• Hepatic impairment

• Elderly patients

Off-label uses

• Heart failure

• Angina pectoris or vasospastic (Prinzmetal's) angina


• Hypersensitivity to drug


Use cautiously in:

• cardiac disease, arrhythmias, severe hepatic or renal impairment

• elderly patients

• pregnant or breastfeeding patients

• children (safety not established).


• Give without regard to meals.

• Make sure patient swallows tablet whole without crushing or chewing.

Adverse reactions

CNS: headache, drowsiness, dizziness, syncope, nervousness, anxiety, psychiatric disturbances, paresthesia, insomnia, asthenia, confusion, irritability

CV: chest pain, peripheral edema, hypotension, palpitations, tachycardia, angina, arrhythmias, myocardial infarction, atrioventricular block

EENT: rhinorrhea, sneezing, pharyngitis

GI: nausea, vomiting, diarrhea, constipation, abdominal discomfort, dyspepsia, abdominal cramps, flatulence, dry mouth

Hematologic: anemia

Musculoskeletal: back pain

Respiratory: bronchitis

Skin: dermatitis, rash, pruritus, urticaria, erythema

Other: dysgeusia, gingival hyperplasia, facial edema, thirst, warm sensation


Drug-drug. Antifungals, cimetidine, erythromycin, propranolol, ranitidine: increased felodipine blood level, increased risk of toxicity

Barbiturates, hydantoins: decreased felodipine blood level

Beta-adrenergic blockers, digoxin, disopyramide, phenytoin: bradycardia, conduction defects, heart failure

Fentanyl, nitrates, other antihypertensives, quinidine: additive hypotension

Nonsteroidal anti-inflammatory drugs: decreased antihypertensive effects

Drug-food. Grapefruit juice: increased felodipine blood level and effects

Drug-behaviors. Acute alcohol ingestion: additive hypotension

Patient monitoring

Don't give to patient with heart block unless he has a pacemaker.

Use extreme caution when administering to patients with pulmonary hypertension, renal insufficiency, heart failure, or compromised ventricular function (especially those receiving beta-adrenergic blockers concurrently).

• Monitor fluid intake and output, and weigh patient daily.

• Monitor ECG and vital signs. Assess for signs and symptoms of heart block.

• Assess for reflex tachycardia, angina, and sustained hypotension.

• Check hepatic profile and alkaline phosphatase level in patients with hepatic impairment.

Patient teaching

• Tell patient drug controls but doesn't cure high blood pressure, so he should keep taking it even if he feels well.

• Instruct patient to move slowly when rising, to avoid light-headedness or dizziness from sudden blood pressure decrease.

• Explain that exercise and hot weather may increase drug's hypotensive effects.

• Tell patient to report peripheral edema, persistent headache, or flushing.

• Advise patient to use hard candy or gum if dry mouth or thirst occurs.

• Tell female patient to inform prescriber if she is pregnant or breastfeeding.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, foods, and behaviors mentioned above.


(fe-loe-di-peen) ,


(trade name),


(trade name)


Therapeutic: antianginals
Pharmacologic: calcium channel blockers
Pregnancy Category: C


Management of hypertension, angina pectoris, and vasospastic (Prinzmetal’s) angina.


Inhibits the transport of calcium into myocardial and vascular smooth muscle cells, resulting in inhibition of excitation-contraction coupling and subsequent contraction.

Therapeutic effects

Systemic vasodilation resulting in decreased BP.
Coronary vasodilation resulting in decreased frequency and severity of attacks of angina.


Absorption: Well absorbed after oral administration, but extensively metabolized, resulting in ↓ bioavailability.
Distribution: Unknown.
Protein Binding: >99%.
Metabolism and Excretion: Mostly metabolized; minimal amounts excreted unchanged by kidneys.
Half-life: 11–16 hr.

Time/action profile (antihypertensive effect)

PO 1 hr 2–4 hrup to 24 hr


Contraindicated in: Hypersensitivity (cross-sensitivity may occur);Sick sinus syndrome;2nd- or 3rd-degree AV block (unless an artificial pacemaker is in place);Systolic BP <90 mm Hg.
Use Cautiously in: Severe hepatic impairment (dose ↓ recommended); Geriatric: Dose ↓ recommended; ↑ risk of hypotension;Severe renal impairment;History of serious ventricular arrhythmias or HF; Obstetric / Lactation / Pediatric: Safety not established.

Adverse Reactions/Side Effects

Central nervous system

  • headache (most frequent)
  • abnormal dreams
  • anxiety
  • confusion
  • dizziness
  • drowsiness
  • nervousness
  • psychiatric disturbances
  • weakness

Ear, Eye, Nose, Throat

  • blurred vision
  • disturbed equilibrium
  • epistaxis
  • tinnitus


  • cough
  • dyspnea


  • arrhythmias (life-threatening)
  • HF (life-threatening)
  • peripheral edema (most frequent)
  • chest pain
  • hypotension
  • palpitations
  • syncope
  • tachycardia


  • anorexia
  • constipation
  • diarrhea
  • dry mouth
  • dysgeusia
  • dyspepsia
  • ↑ liver enzymes
  • nausea
  • vomiting


  • dysuria
  • nocturia
  • polyuria
  • sexual dysfunction
  • urinary frequency


  • dermatitis
  • erythema multiforme
  • flushing
  • ↑ sweating
  • photosensitivity
  • pruritus/urticaria
  • rash


  • gynecomastia
  • hyperglycemia


  • anemia
  • leukopenia
  • thrombocytopenia


  • weight gain


  • joint stiffness
  • muscle cramps


  • paresthesia
  • tremor


  • stevens-johnson syndrome (life-threatening)
  • gingival hyperplasia


Drug-Drug interaction

Additive hypotension may occur when used concurrently with fentanyl, other antihypertensives, nitrates, acute ingestion of alcohol, or quinidine.Antihypertensive effects may be ↓ by concurrent use of NSAIDs.Ketoconazole, itraconazole, propranolol, and erythromycin ↓ metabolism and ↑ blood levels and the risk of toxicity (dose ↓ may be necessary).Grapefruit juice ↑ serum levels and effect.


Oral (Adults) 5 mg/day (2.5 mg/day in geriatric patients); may ↑ q 2 wk (range 5–10 mg/day; not to exceed 10 mg/day).

Availability (generic available)

Extended-release tablets: 2.5 mg, 5 mg, 10 mg

Nursing implications

Nursing assessment

  • Monitor BP and pulse before therapy, during dosage titration, and periodically during therapy. Monitor ECG periodically during prolonged therapy.
    • Monitor intake and output ratios and daily weight. Assess for signs of HF (peripheral edema, rales/crackles, dyspnea, weight gain, jugular venous distention).
  • Assess for rash periodically during therapy. May cause Stevens-Johnson syndrome. Discontinue therapy if severe or if accompanied with fever, general malaise, fatigue, muscle or joint aches, blisters, oral lesions, conjunctivitis, hepatitis, and/or eosinophilia.
  • Angina: Assess location, duration, intensity, and precipitating factors of patient’s anginal pain.
  • Hypertension: Check frequency of refills to monitor adherence.
  • Lab Test Considerations: Total serum calcium concentrations are not affected by calcium channel blockers.
    • Monitor serum potassium periodically. Hypokalemia ↑ risk of arrhythmias and should be corrected.
    • Monitor renal and hepatic functions periodically during long-term therapy. May cause ↑ in hepatic enzymes after several days of therapy, which return to normal upon discontinuation of therapy.

Potential Nursing Diagnoses

Ineffective tissue perfusion (Indications)
Acute pain (Indications)


  • Do not confuse Plendil with Isordil.
  • Oral: May be administered without regard to meals. May be administered with meals if GI irritation becomes a problem.
  • Swallow tablets whole; do not break, crush, or chew. Empty tablets that appear in stool are not significant.

Patient/Family Teaching

  • Advise patient to take medication as directed, even if feeling well. If a dose is missed, take as soon as possible unless almost time for next dose; do not double doses. May need to be discontinued gradually.
    • Instruct patient on correct technique for monitoring pulse. Instruct patient to contact health care professional if heart rate is <50 bpm.
    • Advise patient to avoid grapefruit or grapefruit juice during therapy.
    • Caution patient to change positions slowly to minimize orthostatic hypotension.
    • May cause drowsiness or dizziness. Advise patient to avoid driving or other activities requiring alertness until response to the medication is known.
    • Instruct patient on importance of maintaining good dental hygiene and seeing dentist frequently for teeth cleaning to prevent tenderness, bleeding, and gingival hyperplasia (gum enlargement).
    • Instruct patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to avoid concurrent use of alcohol or OTC medications and herbal products, especially cold preparations, without consulting health care professional.
    • Advise patient to notify health care professional if rash, irregular heartbeat, dyspnea, swelling of hands and feet, pronounced dizziness, nausea, constipation, rash, or hypotension occurs or if headache is severe or persistent.
    • Caution patient to wear protective clothing and to use sunscreen to prevent photosensitivity reactions.
    • Advise patient to inform health care professional of medication regimen before treatment or surgery.
  • Angina: Instruct patient on concurrent nitrate or beta-blocker therapy to continue taking both medications as directed and to use SL nitroglycerin as needed for anginal attacks.
    • Advise patient to contact health care professional if chest pain does not improve or worsens after therapy; occurs with diaphoresis or shortness of breath; or if severe, persistent headache occurs.
    • Caution patient to discuss exercise restrictions with health care professional before exertion.
  • Hypertension: Encourage patient to comply with other interventions for hypertension (weight reduction, low-sodium diet, smoking cessation, moderation of alcohol consumption, regular exercise, and stress management). Medication controls but does not cure hypertension.
    • Instruct patient and family in proper technique for monitoring BP. Advise patient to take BP weekly and to report significant changes.

Evaluation/Desired Outcomes

  • Decrease in BP.
  • Decrease in frequency and severity of anginal attacks.
    • Decrease in need for nitrate therapy.
    • Increase in activity tolerance and sense of well-being.


A brand name for FELOPIDINE.
References in periodicals archive ?
Under the terms of the agreement, CMS will pay AstraZeneca $310 million for the license to sell Plendil in China.
Grapefruit and grapefruit juice are also known to interact with Plendil Extended-Release tablets and Procardia (calcium-channel-blockers), Premarin (a hormone preparation), and Xanax (for anxiety and panic), according to the 2004 Physicians' Desk Reference Companion Guide.
Because when doctors scribble, Isordil can become Plendil, and that's a prescription for trouble.
Cozaar (an angiotensin II receptor antagonist) and Plendil (calcium channel blocker), generally are well tolerated without many side effects.
Although Plendil has a recommended maximum daily dose of 10 milligrams, the pharmacist filled the prescription with directions to take the drug at the dose Kolluru had prescribed for Isordil.
I have been prescribed Lanzoprazol for excessive acid production and Plendil 5 and Bendrafluozide for hypertension.
Isoptin/Calan/Verelan, Cardizem, Procardia/Adalat, Cardene, Plendil, Norvasc, DynaCirc, Vascor
Felodipine is the AB-rated generic equivalent to the calcium channel blocker drug Plendil and is indicated for the treatment of hypertension.
These products are Atacand, Lexxel, Plendil and Entocort as well as certain products currently in clinical development.
Some of the drugs that interact with the compounds in grapefruit include cholesterol-lowering statins like Mevacor and Lipitor; antianxiety drugs, like BuSpar and Valium; and drugs for high blood pressure like Plendil and Sular.
Grapefruit and grapefruit juice are also known to interact with Plendil Extended-Release tablets and Procardia (calcium channel blockers), Premarin (a hormone preparation), and Xanax (for anxiety and panic), according to the 2004 Physicians' Desk Reference Companion Guide.