Also found in: Dictionary, Encyclopedia.
Related to Platinol: cisplatin
trademark for a preparation of cisplatin, an antineoplastic agent.
A trademark for the drug cisplatin.
a trademark for an antineoplastic (cisplatin).
cisplatinA chemotherapeutic that forms covalent bonds and crosslinks with DNA, which is used for head and neck, ovarian, testicular, and bladder cancers and lymphomas.
Nephrotoxicity, nausea, sensory neuropathy.
Management for adverse effects
• Nephrotoxicity: adequate hydration to maintain renal flow and high chloride concentration.
• Nausea: ondansetron, a selective antagonist of serotonin S3 receptors.
• Neuropathy: amifostine, growth factors, glutathione, Org 2766, acetyl-L-carnitine, vitamin E have all been tried; per Cochrane review, none proved effective; more studies are needed.