CD36

(redirected from Platelet collagen receptor)

CD36

a transmembrane protein present on monocytes, platelets, megakaryocytes, the umbilical vein, small-vessel endothelium, reticulocytes, and mammary epithelium that may be involved in signal transduction; expressed in myeloproliferative disorders.

CD36

A gene on chromosome 7q11.2 that encodes the fourth major platelet surface glycoprotein, which is a receptor for thrombospondin. It is acts as a cell adhesion molecule, binding to collagen, thrombospondin, anionic phospholipids, oxidised LDL, long-chain fatty acids and Plasmodium falciparum-parasitised erythrocytes.
 
Molecular pathology
Defects in CD36 cause platelet glycoprotein deficiency; genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7.
References in periodicals archive ?
6] Platelet collagen receptor glycoprotein VI (pGPVI) is the key regulator of platelet activation and aggregation at sites of vascular injury where collagen is exposed (1, 2).
Expression of platelet collagen receptor VI is associated with acute coronary syndrome.
Platelet collagen receptor glycoprotein VI as a possible novel indicator for the acute coronary syndrome.
Influence of platelet count on the expression of platelet collagen receptor glycoprotein VI (GPVI) in patients with acute coronary syndrome.
Local delivery of soluble platelet collagen receptor glycoprotein VI inhibits thrombus formation in vivo.
6] Nonstandard abbreviations: ACS, acute coronary syndrome; pGPVI, platelet collagen receptor glycoprotein VI; SAP, stable angina pectoris; ECG, electrocardiogram; sGPVI, soluble GPVI; CAD, coronary artery disease; NSTEMI, non-STelevation myocardial infarction; STEMI, ST-elevation MI; CRP, C-reactive protein; mAb, monoclonal antibody; MFI, mean fluorescence intensity; AUC, area under the curve; S/N, signal-to-noise ratio.
873] of the platelet collagen receptor integrin [[alpha].
The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to Fc[alpha][psi] and the natural killer receptors.
The GPIa C807T dimorphism associated with platelet collagen receptor density is not a risk factor for myocardial infarction.
The GPIa-C807T polymorphism on the platelet collagen receptor GPIa-IIa and the development of deep vein thrombosis [abstract].
Molecular cloning, genomic structure, chromosomal localization, and alternative splice forms of the platelet collagen receptor glycoprotein VI.
Recent advances in thrombosis and hemostasis: platelet collagen receptors.

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