plasminogen (redirected from Plasminogen activator inhibitor)

plasminogen /plas·min·o·gen/ (plaz-min´ah-jen) the inactive precursor of plasmin, occurring in plasma and converted to plasmin by the action of urokinase.

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plas·min·o·gen (plz-mn-jn)

n.

The inactive precursor to plasmin that is found in body fluids and blood plasma. Also called profibrinolysin.

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plasminogen.

See fibrinogen.

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plasminogen (plazmin´ōjen),

n the precursor of plasmin found in plasma. It is probably activated by a tissue factor or by a blood activator, which first must be activated by a blood or tissue fibrinolysokinase. Formerly called
profibrinolysin. See also plasmin.

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plasminogen

the inactive precursor of plasmin, occurring in plasma and converted to plasmin by activators present in most tissues, blood, vessel walls and body fluids; called also profibrinolysin.

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plasminogen activator inhibitor

can protect the fibrin clot from premature lysis; called also PA inhibitor.

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plasminogen

An 88 kD single-stranded plasmin proenzyme present in the circulation which is converted to plasmin by cleavage of the Arg-Val bond; it is synthesized in the liver, produced or stored in eosinophils and forms complexes with fibrinogen and fibrin; during coagulation, large amounts of plasminogen are integrated in the fibrin clot ↑ in DVT, infection, inflammation, CA, MI, OCs, pregnancy, physical stress, surgery, trauma ↓ in Cirrhosis, other liver disease, DIC, fibrinolysis, hyaline membrane disease–RDS of newborn, renal disease, post-surgery–eg, CABG, thrombosis Normal 2.5-5.2 U/mL–US: 20 mg/dL