Plasmapheresis

Plasmapheresis 

Definition

Plasmapheresis is a blood purification procedure used to treat several autoimmune diseases. It is also known as therapeutic plasma exchange.

Purpose

In an autoimmune disease, the immune system attacks the body's own tissues. In many autoimmune diseases, the chief weapons of attack are antibodies, proteins that circulate in the bloodstream until they meet and bind with the target tissue. Once bound, they impair the functions of the target, and signal other immune components to respond as well.

Plasmapheresis is used to remove antibodies from the bloodstream, thereby preventing them from attacking their targets. It does not directly affect the immune system's ability to make more antibodies, and therefore may only offer temporary benefit. This procedure is most useful in acute, self-limited disorders such as Guillain-Barré syndrome, or when chronic disorders, such as myasthenia gravis, become more severe in symptoms. In these instances, a rapid improvement could save the patient's life. Neurologic diseases comprise 90% of the diseases that could profit from plasmapheresis.

Precautions

Patients with clotting disorders may not be suitable candidates for plasmapheresis.

Description

The basic procedure consists of removal of blood, separation of blood cells from plasma, and return of these blood cells to the body's circulation, diluted with fresh plasma or a substitute. Because of concerns over viral infection and allergic reaction, fresh plasma is not routinely used. Instead, the most common substitute is saline solution with sterilized human albumin protein. During the course of a single session, two to three liters of plasma is removed and replaced.

Plasmapheresis requires insertion of a venous catheter, either in a limb or central vein. Central veins allow higher flow rates and are more convenient for repeat procedures, but are more often the site of complications, especially bacterial infection.

When blood is outside the body, it must be treated to prevent it from clotting. While most of the anticlotting agent is removed from the blood during treatment, some is returned to the patient.

Three procedures are available:

A single plasmapheresis session may be effective, although it is more common to have several sessions per week over the course of two weeks or more.

Preparation

Good nutrition and plenty of rest make the procedure less stressful. The treating physician determines which of the patient's medications should be discontinued before the plasmapheresis session.

Aftercare

The patient may experience dizziness, nausea, numbness, tingling, or lightheadedness during or after the procedure. These effects usually pass quickly, allowing the patient to return to normal activities the same day.

Risks

Reinfusion (replacement) with human plasma may cause anaphylaxis, a life threatening allergic reaction. All procedures may cause a mild allergic reaction, leading to fever, chills, and rash. Bacterial infection is a risk, especially when a central venous catheter is used. Reaction to the citrate anticoagulant used may cause cramps and numbness, though these usually resolve on their own. Patients with impaired kidney function may require drug treatment for the effects of citrate metabolism.

Plasma contains clotting agents, chemicals that allow the blood to coagulate into a solid clot. Plasma exchange removes these. Bleeding complications are rare following plasmapheresis, but may require replacement of clotting factors.

Normal results

Plasmapheresis is an effective temporary treatment for:

Other conditions may respond to plasmapheresis as well. Beneficial effects are usually seen within several days. Effects commonly last up to several months, although longer-lasting changes are possible, presumably by inducing shifts in immune response.

Resources

Books

Samuels, Martin, and Steven Feske, editors. Office Practice of Neurology. New York: Churchill Livingstone, 1996.

Key terms

Anaphylaxis — Also called anaphylactic shock, it is a severe allergic reaction to a foreign substance that the patient has had contact with. Penicillin is an example of a substance that causes severe allergic reactions for some people.

Antibody — Chemicals produced by the body to defend it against bacteria, viruses, or other cells foreign to the body (antigens). Each specific antibody reacts against a specific foreign body. Antibodies are also termed immunoglobulins.

Autoimmune — Autoimmune refers to the body's development of intolerance of the antigens on its own cells.

Hemodialysis — A method to take out unwanted parts of the blood. The patient's blood is run through a catheter and tubing into a machine called a dialyzer, which filters out the unwanted blood component.

Plasma — Plasma makes up 50% of human blood. It is a watery fluid that carries red cells, white cells, and platelets throughout the body.

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plasmapheresis /plas·ma·phe·re·sis/ (plaz?mah-fe-re´sis) the removal of plasma from withdrawn blood, with retransfusion of the formed elements into the donor; generally, type-specific fresh frozen plasma or albumin is used to replace the withdrawn plasma. The procedure may be done for purposes of collecting plasma components or for therapeutic purposes.

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plas·ma·phe·re·sis (plzm-f-rss, -fr-)

n.

A process in which plasma is taken from donated blood and the remaining components, mostly red blood cells, are returned to the donor.

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plasmapheresis

the removal of plasma from withdrawn blood, with retransfusion of the formed elements into the donor; generally, type-specific fresh frozen plasma or albumin is used to replace the withdrawn plasma. The procedure may be done for purposes of collecting plasma components or for therapeutic purposes. See also plasma exchange.