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pituitary apoplexy

   Also found in: Encyclopedia, Wikipedia, Hutchinson 0.04 sec.
pituitary apoplexy
Acute life-threatening hemorrhagic infarction of the anterior pituitary or adenohypophysis, often associated with an infarcted pituitary adenoma or other tumor; PA may occur spontaneously, or due to an 'obstetric' hemorrhage–eg, Sheehan syndrome, regional RT, ↑ intracranial pressure, or systemic anticoagulation Clinical The PA 'syndrome' may be transient or permanent; it is characterized by sudden headache, loss of vision, ophthalmoplegia, and if severe, shock Lab ↓ Growth hormone, ↓ gonadotropins, ↓ ACTH, ↓ TSH–with hypothyroidism, abnormal prolactin secretion, rarely, diabetes insipidus Treatment Hormone replacement, bromocriptine


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