picrotoxin


Also found in: Dictionary, Encyclopedia, Wikipedia.
Related to picrotoxin: Bicuculline, CNQX

pic·ro·tox·in

(pik'rō-tok'sin),
A bitter neutral principle derived from the fruit of Anamirta cocculus (family Menispermaceae); a CNS stimulant; a convulsant and GABA antagonist used extensively in experimental procedures studying seizure mechanisms.
Synonym(s): cocculin
[G. pikros, bitter, + toxicon, poison]

picrotoxin

(pĭk′rə-tŏk′sĭn)
n.
A bitter crystalline compound, C30H34O13, derived from the seed of a tropical Asian woody vine (Anamirta cocculus) and used as a stimulant, especially in treating barbiturate poisoning.

picrotoxin

[pik′rōtok′sin]
Etymology: Gk, pikros, bitter, toxikon, poison
a central nervous system stimulant obtained from the seeds of Anamirta cocculus, formerly used as an antidote for acute barbiturate poisoning.

picrotoxin

a central nervous system and respiratory stimulant formerly used in barbiturate and other anesthetic poisonings; extracted from the seeds of the plant Anamirta cocculus.
References in periodicals archive ?
The negative control group: mice received the amount of 10 ml/kg normal saline 20 min before picrotoxin injection.
A]R, showing the residues that form the binding site for picrotoxin (PTX) and RDX [closed circles in (C): residues numbered 1'-23' from the N-terminal bottom; open circles represent residues that are not part of the binding site].
Coexistence in DUM neurons of two GluCl channels that differ in their picrotoxin sensitivity.
The effect of L-arginine on the memory impairing action of phenobarbitone in rats that convulsed after the injection of picrotoxin.
into the SNS was terminated after 5 seconds using picrotoxin (a [GABA.
Administration of a drug called picrotoxin breaks down these rhythmic pulses in bee brains, the investigators report.
These findings are consistent with an account of the GABA/benzodiazepine receptor complex in which both valproate and picrotoxin act at the chloride ion channel, while chlordiazepoxide acts at the benzodiazepine receptor and this is antagonized by flumazenil (in earlier publications this drug was referred to as Ro15-1788).
6) Pediculicide Drug Products: Benzocaine, Benzyl Alcohol, Benzyl Benzoate, Chlorophenothane (Dichlorodiphenyltrichloroethane), Cocunut Oil Soap (Aqueous), Copper Oleate, Docusate Sodium, Formic Acid, Isobornyl Thiocyanoacetate, Picrotoxin, Propylene Glycol, Sabadilla Alkaloids, Sulfur (Sublimed), Thiocyanoacetate.
METHODS AND RESULTS: By screening the affinity of RDX for a number of neurotransmitter receptors, we found that RDX binds exclusively to the picrotoxin convulsant site of the [gamma]-aminobutyric acid type A ([GABA.
Effects of Picrotoxin (PTX) on Phonotaxis in Cricket.
GABA was thought to be the probable candidate for inhibition of REM-OFF neurons (187) because of the (i) presence of GABA-ergic interneurons and terminals in LC (84,95,188); (ii) the presence of GABA-ergic receptors (189,190) on the neurons in LC; (iii) increased GABA levels in LC during REM sleep (167); (iv) reduction of REM sleep by microinjection of picrotoxin, a GABA-A receptor antagonist, in LC (191); (v) activation of GABA-ergic neurons in LC during REM sleep (192) ; and (vi) inhibition of NA-ergic neurons in LC by GABA (193).
Picrotoxin, a known inhibitor of the convulsant binding site, was used to determine nonspecific binding.