phospholipase A2

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phos·pho·lip·ase A2

an enzyme that catalyzes the hydrolysis of a lecithin to a lysolecithin by removing the 2-acyl group; also acts on other phospholipids by removing a fatty acid from the 2-position; this enzyme has an important role in prostaglandin and leukotriene biosynthesis.
Synonym(s): lecithinase A, phosphatidase, phosphatidolipase


A gene on chromosome 8q23.1 that encodes an adapter protein which regulates a broad spectrum of general and specialised signalling pathways by binding to a large number of partners, usually by recognising a phosphoserine or phosphothreonine motif.

phospholipase A2

enzyme catalyzing the hydrolysis of the fatty acyl group esterified in the 2-position of a phospholipid. Key enzyme in the release of arachidonic acid from this position for subsequent conversion to the eicosanoid group of humoral agents.
References in periodicals archive ?
Darapladib binds to lipoprotein-associated phospholipase A2 with meaningful interaction.
Targeting of venom phospholipases: The strongly anticoagulant phospholipase A2 from Naja nigricollis venom binds to coagulation factor Xa to inhibit the prothrombinase complex.
Animal studies show that tissue damage occurs as early as 5 minutes after intradermal injection of phospholipase A2.
An inhibitor of phospholipase A2 group IIa modulates adipocyte signaling and protects against diet-induced metabolic syndrome in rats.
Allelic association analysis of phospholipase A2 genes with schizophrenia.
Functional coupling between secretory phospholipase A2 and cyclooxyge-nase-2 and its regulation by cytosolic group IV phospholipase A2.
Gravitational force causes the activation of phospholipase A2, an enzyme involved in the generation of prostaglandins and leukotrienes.
Treating residual cardiovascular risk: will lipoprotein-associated phospholipase A2 inhibition live up to its promise?
Cytosolic phospholipase A2 participates with TNF-alpha in the induction of apoptosis of human macrophages infected with Mycobacterium tuberculosis H37Ra.
2:153-6, 2006 Lipoprotein-associated phospholipase A2, vascular inflammation and cardiovascular risk prediction.
Polybitoxins: A group pf phospholipase A2 from the venom of the neotropical social wasp paulistina (Polybia paulista).

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