phosphoenolpyruvic acid carboxykinase

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phos·pho·enol·pyr·u·vic ac·id car·box·y·kin·ase

an enzyme that catalyzes the reaction of oxaloacetate and GTP to form phosphoenolpyruvic acid, CO2, and GDP; a key enzyme in gluconeogenesis; the biosynthesis of this enzyme is decreased by insulin.
References in periodicals archive ?
Franckhauser S, Munoz S, Elias I, and others, Adipose overexpression of phosphoenolpyruvate carboxykinase leads to high susceptibility to diet-induced insulin resistance and obesity.
Transcriptional regulation of pyruvate kinase and phosphoenolpyruvate carboxykinase in the adductor muscle of the oyster Crassostrea gigas during prolonged hypoxia.
The continuous treatment with borapetoside A for 7 days induced the phosphorylation of IR, Akt, AS160, and GLUT2, and decreased the expression of phosphoenolpyruvate carboxykinase (PEPCK) in the liver of the Type 1 DM bearing mice.
In invertebrate models for example, forkhead transcription factor family O (FOXO) transcription factors in this pathway regulate the rate of aging in response to dietary cues, and in vertebrates, obesity and age-induced deficits in the same pathway are thought to contribute to dysregulation of hepatic gluconeogenesis through genes such as phosphoenolpyruvate carboxykinase (PEPCK).
The supernatant was separated and divided into three parts for measurement of glucokinase (GK), phosphoenolpyruvate carboxykinase (PEPCK), and glucose-6-phosphatase (G6Pase) activity.
The cortisol-induced metabolic abnormalities includes many mechanisms, mainly impaired insulin sensitivity, altered lipid metabolism, enhanced adipogenesis and gluconeogenesis; gluconeogenesis is increased due to increased hepatic phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase enzymes activities (Radahmadi et al.
The modification causes the mice to express in skeletal muscle an enzyme called phosphoenolpyruvate carboxykinase (PEPCK-C), which is normally found in liver and adipose tissue and is involved in energy metabolism.
A vicinal dithiol containing an essential cysteine in phosphoenolpyruvate carboxykinase (guanosine triphosphate) from cytosol of rat liver.
When SARA was induced, acyl-CoA synthetase (ACS) and cytochrome b5 involved in lipid metabolism were up-regulated, phosphoenolpyruvate carboxykinase (PEPCK) involved in glucose metabolism was downregulated, while enolase was up-regulated.
2,3,7,8-tetraclhlorodibenzo-p-dioxin blocks the physiological regulation of hepatic phosphoenolpyruvate carboxykinase activity in primary rat hepatocytes.
We also examined the gene expression of the gluconeogenesis enzymes glucose-6-phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK) in the liver (data not shown).
1) (ERP60) 100 WD repeat protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1) 101 WD repeat protein 1 (Actin-interacting protein 1) (AIP1) 102 Phosphoenolpyruvate carboxykinase [GTP], mitochondrial precursor 103 Transketolase (EC 2.
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