phosphatidylinositol 4,5-bisphosphate


Also found in: Wikipedia.

phos·pha·ti·dyl·in·o·si·tol 4,5-·bis·phos·phate (PIP2, PtdIns(4,5)P2),

phosphatidylinositol with two additional sites of phosphorylation; an important constituent of cell membrane phospholipids as well as a precursor of the second messengers, diacylglycerol and inositol 1,4,5-trisphosphate.
References in periodicals archive ?
Positively charged AA on positions 2 and 5 are also highly conserved and suggested to interact with phosphatidylinositol 4,5-bisphosphate ([PIP.
Of these 46 genes, phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), proto-oncogene c-Kit (KIT), and tumor protein p53 (TP53) were the most common mutated genes.
Rapid accumulation of phosphatidylinositol 4,5-bisphosphate and inositol 1,4,5-trisphosphate correlates with calcium mobilization in salt-stressed arabidopsis.
23,24) The rise in the intracellular calcium concentration causes the activation of phosphatidylinositol 4,5-bisphosphate ([PIP.
Afterwards, the activated PI3K catalyzes the synthesis of phosphatidylinositol 3,4,5-triphosphate (PIP3), from phosphatidylinositol 4,5-bisphosphate (PIP2) [88].
Hypo-osmotic stress activates Plc1p-dependent phosphatidylinositol 4,5-bisphosphate hydrolysis and inositol hexakisphosphate accumulation in yeast.

Full browser ?