Chang Holdings, LLC for ownership to its investigational cancer patent assignment using Phorbol Esters
in the treatment of Hodgkin's Lymphoma.
Jatropha curcas is a non-edible vegetable oil due to the presence of phorbol esters
which accounts for its toxicity.
Not content just to cause pain and blindness, the plant has long-term ideas as well: it contains phorbol esters
, which are not only skin irritants but actually promote cancer development, suppress the immune system and activate dormant Epstein-Barr virus.
TPA, a kind of phorbol esters
, is one of the main irritant compounds in Euphorbiaceae plants.
v-Ha-ras transgene abrogates the initiation step in mouse skin tumorigenesis: effects of phorbol esters
and retinoic acid.
Direct activation of PKC by phorbol esters
(PMA) or a PMA analog, phorbol 12, 13 dibutyrate, desensitizes the receptor.
In previous studies, the Johns Hopkins researchers described how the lung's epithelial cells respond to a number of carcinogens and pro-carcinogens-including phorbol esters
, retinoic-acid deprivation, and tobacco smoke--by changing into squamous cells.
Last fall, we published an article in the journal Leukemia documenting that indeed NB4 cells could be stimulated to differentiate into monocyte/macrophages by combinations of phorbol esters
, 1,25 dihydroxyvitamin [D.
However, unlike "classic" chemical tumor promoters such as phorbol esters
, asbestos "does not appear to activate PKC by a receptor-like interaction," the researchers report in the September CARCINOGENESIS.
In the lab, they added phorbol esters
(tumor-promoting substances) and a solvent ethanol (ethyl alcohol) to human cells and found that the cells began to make a substance they later identified as phosphatidylethanol.
Regulation of normal differentiation in mouse and human myeloid leukemic cells by phorbol esters
and the mechanism of tumor promotion.
They observed that when they applied chemical compounds called phorbol esters
to cancerous cells, the cells produced a substance later identified as phosphatidylethanol.