phorbol

(redirected from Phorbol ester)

phor·bol

(fōr'bol),
The parent alcohol of the cocarcinogens, which are 12,13(9,9a) diesters of phorbol found in croton oil; the hydrocarbon skeleton is a cyclopropabenzazulene; phorbol esters mimic 1,2-diacylglycerol as activators of protein kinase C.

phorbol

/phor·bol/ (for´bol) a polycyclic alcohol occurring in croton oil; it is the parent compound of the phorbol esters.
phorbol ester  any of several esters of phorbol that are potent cocarcinogens, activating a cellular protein kinase; used in research to enhance the induction of mutagenesis or tumors by carcinogens.
References in periodicals archive ?
The lead "platform drug" (RP-323) is a phorbol ester, which induces differentiation and/or apoptosis in multiple cell lines and primary cells, activates protein kinase C (PKC), and modulates the activity of multiple downstream cell signaling pathways, including mitogen-activated protein kinase (MAPK) pathways.
Although Jatropha oils and surplus agriculture residues are listed as promising options for feedstock for production of non-food biofuels, Jatropha contain toxic materials such as phorbol ester, so their detoxification is needed for utilization as biofuels.
A novel phorbol ester, 12-deoxyphorbol 13-(3E,5E-decadienoate), with anti-human immunodeficiency virus properties, has been described from leaves and stems of the plant (Erickson et al.
DAT phosphorylation is stimulated in response to PKC activation via phorbol ester stimulation but the effects of phosphorylation on DAT function remain unclear.
Induction of tumors of the liver, lung, ovary and adrenal in adult mice after brief maternal gestational exposure to inorganic arsenic: promotional effects of postnatal phorbol ester exposure on hepatic and pulmonary, but not dermal cancers.
In a major step toward understanding how air pollutants injure the lungs and trigger the cascade of molecular events leading to lung cancer, scientists at the Johns Hopkins School of Public Health have spelled out the molecular process whereby a tumor-promoting toxin, phorbol ester, can activate a gene called SPRR1.
3] treatment needed to precede phorbol ester treatment for differentiation to take place and that the response was both time and dose dependent (Experimental Cell Research, in press).
jujuba through the inhibitory effects on the inflammatory cells activated by Euphorbia kansui and prostratin, a phorbol ester isolated from Euphorbia fischeriana.
Rich Pharmaceuticals' RP-323 is a phorbol ester, which induces differentiation and/or apoptosis in multiple cell lines and primary cells, activates protein kinase C (PKC), and modulates the activity of multiple downstream cell signaling pathways, including mitogen-activated protein kinase (MAPK) pathways.
Involvement of tumor necrosis factor (TNF)-alpha in phorbol ester 12-0-tetradecanoylphorbol-13-acetate (TPA)-induced skin edema in mice.
For example, skin treatment with the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) leads to a reduction of the collagen content of the mouse dermis (Marian 1987; Marian and Mazzucco 1985).