phorbol

(redirected from Phorbol ester)

phor·bol

(fōr'bol),
The parent alcohol of the cocarcinogens, which are 12,13(9,9a) diesters of phorbol found in croton oil; the hydrocarbon skeleton is a cyclopropabenzazulene; phorbol esters mimic 1,2-diacylglycerol as activators of protein kinase C.

phorbol

/phor·bol/ (for´bol) a polycyclic alcohol occurring in croton oil; it is the parent compound of the phorbol esters.
phorbol ester  any of several esters of phorbol that are potent cocarcinogens, activating a cellular protein kinase; used in research to enhance the induction of mutagenesis or tumors by carcinogens.
References in periodicals archive ?
However, Makkar and Becker [5] reported that the presence of a cocktail of anti-nutritional factors like phorbol esters, saponins, tannins, phytates, lectins, hydrocyanides and oxalates prevent its use in animal feeding; phorbol ester is considered the most toxic compound.
Dietary conjugated linoleic acid modulation of phorbol ester skin tumor promotion.
Induction of tumors of the liver, lung, ovary and adrenal in adult mice after brief maternal gestational exposure to inorganic arsenic: promotional effects of postnatal phorbol ester exposure on hepatic and pulmonary, but not dermal cancers.
2013) while three white- rot fungi (Bjerkandera adusta Ganoderma resinaceum and Phlebia rufa) could remove phorbol ester compounds fromJ.
Although Jatropha oils and surplus agriculture residues are listed as promising options for feedstock for production of non-food biofuels, Jatropha contain toxic materials such as phorbol ester, so their detoxification is needed for utilization as biofuels.
damicomis were induced to metamorphose by the phorbol ester TPA at concentrations between [10.
A novel phorbol ester, 12-deoxyphorbol 13-(3E,5E-decadienoate), with anti-human immunodeficiency virus properties, has been described from leaves and stems of the plant (Erickson et al.
DAT phosphorylation is stimulated in response to PKC activation via phorbol ester stimulation but the effects of phosphorylation on DAT function remain unclear.
Taspine, two aporphinic alkaloids, the diterpenes 9(11)-dehydrokaurenic acid, hardwikiic acid, the corresponding new 12-oxo derivative as well as five clerodanes and a phorbol ester were also isolated.
In a major step toward understanding how air pollutants injure the lungs and trigger the cascade of molecular events leading to lung cancer, scientists at the Johns Hopkins School of Public Health have spelled out the molecular process whereby a tumor-promoting toxin, phorbol ester, can activate a gene called SPRR1.
Immunodeficiency of aging: restorative effects of phorbol ester combined with calcium ionophore.