phenoxybenzamine hydrochloride

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[fēnok′sēben′zəmēn]

an irreversible (noncompetitive) alpha₁-adrenergic receptor blocker producing long-lasting blockade.

indications It is prescribed in the control of pheochromocytoma and other instances of hypertensive crisis. If tachycardia is excessive, concomitant administration of propranolol may be necessary.

contraindications Hypotension or known hypersensitivity to this drug prohibits its use.

adverse effects Among the more serious adverse effects are severe hypotension, tachycardia, and GI irritation.

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