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phenanthridine |
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phenanthridium, phenanthridine a group of chemotherapeutic agents used in the treatment of trypanosomiasis. Includes isometamidium, homidium, pyrithidium (Prothidium) and quinapyramine. Want to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit the webmaster's page for free fun content. |
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Led by Professor Cohen-Armon of Tel-Aviv University, the researchers found that potent phenanthridine derived polyADP-ribose polymerase (PARP) inhibitors efficiently eradicate MCF-7 and MDA231 breast cancer cells without impairing normal proliferating cells, such as human epithelial cells (MCF-10A), nor normal non-proliferating cells, such as neurons and cardiomyocytes. Olinger, and Wolfgang Kramer, Millsaps College, Jackson, MS 39210 Quantitative photochemical DNA cleaving studies with nitrogen onium salts were performed using potential DNA intercalators based on the quinoline, isoquinoline and phenanthridine skeletons. Although the interactions of ethidium with DNA have been well characterized, many questions remain regarding the role that the amino substituents (located at positions 3 and 8 on the phenanthridine ring) play in the intercalative binding process. |
phenanthridine |
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