biological activity

(redirected from Pharmacological activity)

biological activity

the inherent capacity of a substance, such as a drug or toxin, to alter one or more chemical or physiological functions of a cell, tissue, organ, or organism. The biological activity of a substance is determined not only by the substance's physical and chemical nature but also by its concentration and the duration of cellular exposure to it. Biological activity may reflect a "domino effect," in which the alteration of one function disrupts the normal activity of one or more other functions.
References in periodicals archive ?
The metabolite of risperidone is 9- hydroxyrisperidone which has pharmacological activity and a half- life of 24 hours.
For this aim the project will train ESRs, focusing on key aspects of nanobiotechnology: (i) design and chemical synthesis of different types of NPs, (ii) related techniques of detection and characterization, (iii) strategies of loading, targeting and delivery of drugs or diagnostic probes; (iv) proof of principle of pharmacological activity including pharmacokinetics and biodistribution.
However, different forms of vitamins and minerals can be absorbed differently and have varying levels of pharmacological activity.
The institute intends to fund grants to researchers who are developing biofluid drug screens based on pharmacological activity of these designer drugs.
Furthermore, EtOHE from the cultivated plant, with 4, 7 or 9 months of cultivation, showed a similar pharmacological activity, as compared to the EtOHE from wild plant, although EtOHE from 4-month-species was somewhat less potent in paw edema models.
The data of biologically active compounds, biochemical structure and the maintenance both in flowers and in others parts of plant is presented; the pharmacological activity and importance in medicine was reviewed.
Ginseng saponins (ginsenosides), the active component of ginseng, are reported to exhibit different types of bioactivity, especially pharmacological activity.
This book looks at the main ellagitannin-rich medicine plants and describes the biological and pharmacological activity, structural diversity, and antimicrobial properties of ellagitannins.
Exposure Band Hazard Description OEL mg /m3 Band 1 Harmful, and/or low 1000-5000 pharmacological activity Band 2 Harmful, and/or moderate 100-1000 pharmacological activity Band 3 Moderately toxic and/or high 10-100 pharmacological activity Band 4 Toxic and/or very high 1-10 pharmacological activity Band 5 Extremely toxic and/or extremely <1 high pharmacological activity
However, understanding the structure of RXR and various ligands (both agonists and antagonists) starts the process of elucidating the correlation between the pharmacological activity of the ligand and the molecular interactions it undergoes with the RXR protein.
Also, the OptimizeIt application suggests modifications of lead compounds for medicinal chemists by enumerating and analyzing combinatorial libraries, based on the parent compound or scaffold within certain user-defined in silico ADME/Tox or physicochemical properties and pharmacological activity constraints.
Once a new chemical entity is identified as having pharmacological activity, it will be offered to aaiPharma.

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