Weber-Christian disease

(redirected from Pfeiffer-Weber-Christian syndrome)
Also found in: Encyclopedia.

Weber-Christian disease

 [va´ber kris´chan]
a disease marked by fever and the formation of crops of tender nodules in the subcutaneous fatty tissues. Called also nodular nonsuppurative panniculitis and Christian-Weber disease.

Web·er-Chris·tian dis·ease

(vā'bĕr kris'chĕn),
relapsing febrile nodular nonsuppurative panniculitis of undetermined cause.Synonym(s): relapsing febrile nodular nonsuppurative panniculitis

Weber-Christian syndrome

A rare idiopathic condition that primarily affects adult females; it is a diagnosis of exclusion.
 
Clinical findings
Crops of subcutaneous nodules on the thighs, abdomen, arms and breasts, accompanied by fever, local inflammation, rheumatic complaints (arthritis, arthralgia, myalgia), hepatosplenomegaly, abdominal pain and episcleritis.
 
Lab
Nonspecific; leukopenia, increased ESR, rheumatoid factor, cryoglobulinemia.
 
DiffDx
Erythema induratum, sarcoidosis, post-injection fat necrosis.

Management
Symptomatic relief with corticosteroids, chloroquine, phenylbutazone.

re·lap·sing fe·brile nod·u·lar non·sup·pur·a·tive pan·ni·cu·li·tis

(rē-lap'sing feb'ril nod'yū-lăr non'sŭp'yŭr-ă-tiv pă-nik'yū-lī'tis)
Nodular fat necrosis of a varietyof possible causes.
Synonym(s): Christian disease (2) , Christian syndrome, Weber-Christian disease.

Christian,

Henry Asbury, U.S. internist, 1876-1951.
Christian disease - (1) Synonym(s): Hand-Schüller-Christian disease; - ; (2) Synonym(s): Weber-Christian disease
Christian syndrome - Synonym(s): Hand-Schüller-Christian disease
Hand-Schüller-Christian disease - see under Hand
Weber-Christian disease - see under Weber, Frederick Parkes

Weber,

Frederick Parkes, English physician, 1863-1962.
Klippel-Trenaunay-Weber syndrome - see under Klippel
Rendu-Osler-Weber syndrome - see under Rendu
Sturge-Kalischer-Weber syndrome - Synonym(s): Sturge-Weber syndrome
Sturge-Weber disease - Synonym(s): Sturge-Weber syndrome
Sturge-Weber syndrome - see under Sturge
Weber-Christian disease - a group of conditions with recurrent subcutaneous nodules, with or without fever or suppuration, followed by depression of the overlying skin. Synonym(s): Christian disease (2); nodular nonsuppurative panniculitis
Weber-Cockayne syndrome - epidermolysis bullosa of the hands and feet.

Weber-Christian disease

see nodular nonsuppurative panniculitis.