In our study, DogCV DNA was detected in lymphoid tissues, including Peyer's patches
, even for dogs 3 and 4, where no clinical or histologic enteric lesions were detectable.
It is also speculated that the formation of immune complexes of pectic polysaccharide-reacting natural IgA antibody with the active pectic polysaccharides in the intestinal fluid may not only participate in incorporation of the active pectic polysaccharides into Peyer's patches but also activate complement components in the fluid to result in certain modulations of the intestinal immune system.
Selective adherence of IgA to murine Peyer's patches M cells: evidence for a novel IgA receptor.
, the lymphoid bodies that surround the lumen of the small and large intestines, can be damaged by antibiotics and environmental toxins over a lifetime and may not produce enough T cells.
Lymphocytes in the intestinal mucosa such as Peyer's patches
are eliminated from the mucosa and migrated through the mesentric lymph nodes to reach systemic circulation to regulate defense system of the other mucosal sites like upper respiratory tract as well as regulates systemic immune response (McGhee et al.
Salmonella typhimurium initiates murine infection by penetrating and destroying the specialized epithelial M cells of the Peyer's patches
Gut-associated lymphoid tissue (GALT) is represented by Peyer's patches
(think about beefing up Peyer's patches
with Rebas, from Pleo Sanum--MG), tonsils, mesenteric lymph nodes, and appendix.
Although integrins are not present on the apical surface of enterocytes, they are located on the apical surface of microfold cells found in Peyer's patches
along the intestinal lumen (18).