peripartum cardiomyopathy


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per·i·par·tum car·di·o·my·op·a·thy

cardiac failure due to heart muscle disease in the period before, during, or after delivery.

peripartum cardiomyopathy

Cardiology A rare but often fatal–50-85% mortality–form of dilated cardiomyopathy, defined as heart failure–HF occurring in the last month of pregnancy or within 5 months of delivery in absence of an identifiable cause of HF, and without demonstrable preexisting or concurrent heart disease; findings include cardiothoracic ratio > 0.55, a left ventricular ejection fraction < 50%, and a diastolic dimension > 95th percentile for age and body-surface area or recent pregnancy where heart muscle is weakened and cannot pump blood efficiently; ↓ heart function affects lungs, liver, and other systems Risk factors Obesity, personal or family Hx of heart disease–eg, myocarditis, use of certain drugs, smoking, alcoholism, multiple pregnancies, race, malnourishment, muscle degeneration, fibrosis

peripartum cardiomyopathy

Dilated cardiomyopathy occurring either in the last month of pregnancy or in the six months after delivery. Its cause is unknown, but it occurs more often in older and multiparous women.
See also: cardiomyopathy
References in periodicals archive ?
Intravenous immune globulin in the therapy of peripartum cardiomyopathy.
Maternal and fetal outcomes of subsequent pregnancies in women with peripartum cardiomyopathy.
In a recent study that was conducted at a large medical center, ejection fractions improved by at least 15% in 62% of women with peripartum cardiomyopathy, remained unchanged in 25%, and declined in 13% (Am.
Elkayam concludes in his review that a normalization of LV function may occur in more than 50% of women with peripartum cardiomyopathy, mostly within 2-6 months after diagnosis.
van Spaendonck-Zwarts offered three lines of evidence in support of the hypothesis that a subset of peripartum cardiomyopathy is actually a first manifestation of familial dilated cardiomyopathy rather than, as previously assumed, a sporadic event.
One, in reviewing a Dutch cohort of 90 proven dilated cardiomyopathy families, she and her coinvestigators discovered five families, or 6%, had members with peripartum cardiomyopathy.
Peripartum cardiomyopathy is a rare disorder, with an estimated incidence in the United States of 1 case in 4,075 live births, noted Dr.
Second, when the Dutch team reviewed their 10 most recent cases of peripartum cardiomyopathy, they found 3 of the 10 women did not show a full recovery of left ventricular ejection fraction and dimensions.
Third, an in-depth genetic analysis conducted in one of the dilated cardiomyopathy families with a member who had peripartum cardiomyopathy revealed a mutation in TNNC1, the gene encoding cardiac troponin C.
Together, these findings strongly suggest that a subset of peripartum cardiomyopathy is part of the spectrum of familial dilated cardiomyopathy presenting in the peripartum period," said Dr.
Close follow-up of any case of peripartum cardiomyopathy is critical," Dr.