peptide nucleic acid

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peptide nucleic acid

Abbreviation: PNA
A synthetic nucleic acid analog in which natural nucleotide bases are linked to a peptide-like backbone instead of the sugar-phosphate backbone found in DNA and RNA. PNA has numerous uses in gene regulation, splicing, and therapy; in hybridization; and as a molecular diagnostic assay.
See also: acid

peptide nucleic acid (PNA)

a POLYNUCLEOTIDE analogue, in which the sugar-phosphate backbone is replaced by amide bonds. Two strands of PNA can hybridize to form a DNA-like double-stranded helix. A strand of PNA can also hybridize with a normal polynucleotide and this property may be exploited in DNA MICROARRAYS.
References in periodicals archive ?
OliPass rationally designed peptide nucleic acids possessing good cell permeability and have demonstrated in vivo antisense therapeutic activity at an unprecedentedly small dose without relying on complex formulation.
Some analogs such as Peptide Nucleic Acids (PNA) are fairly stable.
He will present his group's work on the synthesis and properties of nucleobase-modified peptide nucleic acids at the 7th International Symposium on BiomolecularChemistry (ISBOC-7) held at the University of Sheffield, U.
The functional domain could be created with a variety of backbone modifications, including second-generation chemistry, peptide nucleic acids, and locked nucleic acids.
18 ELECTRONIC CIRCULAR DICHROISM OF PEPTIDE NUCLEIC ACIDS AND THEIR ANALOGUES
Stability of peptide nucleic acids in human serum and cellular extracts.
those containing peptide nucleic acids (PNAs) as detection elements.
Advanced Viral Research is a biotechnology company specializing in the development of peptide nucleic acids for pharmaceutical use.
To better understand the brain peptide he was researching, Richelson and his colleagues used peptide nucleic acids (PNAs), a new type of molecule, to create antisense compounds targeting neurotensin.