peptide nucleic acid


Also found in: Dictionary, Thesaurus, Legal, Acronyms, Encyclopedia, Wikipedia.

peptide nucleic acid

Abbreviation: PNA
A synthetic nucleic acid analog in which natural nucleotide bases are linked to a peptide-like backbone instead of the sugar-phosphate backbone found in DNA and RNA. PNA has numerous uses in gene regulation, splicing, and therapy; in hybridization; and as a molecular diagnostic assay.
See also: acid

peptide nucleic acid (PNA)

a POLYNUCLEOTIDE analogue, in which the sugar-phosphate backbone is replaced by amide bonds. Two strands of PNA can hybridize to form a DNA-like double-stranded helix. A strand of PNA can also hybridize with a normal polynucleotide and this property may be exploited in DNA MICROARRAYS.
References in periodicals archive ?
Peptide nucleic acid fluorescence in-situ hybridization-based identification of Candida albicans and its impact on mortality and antifungal therapy costs.
Fluorescent in situ hybridization assay using peptide nucleic acid probes for differentiation between tuberculous and nontuberculous mycobacterium species in smears of mycobacterium cultures.
Advanced Viral Research is a biotechnology company specializing in the development of peptide nucleic acids for pharmaceutical use.
5 hours fluorescence in situ hybridization (FISH) assay uses fluorescence-labeled peptide nucleic acid (PNA) probes that target the species-specific ribosomal RNA (rRNA) in bacteria and yeast.
Based on the peptide nucleic acid fluorescence in situ hybridization (PNA FISH) technology, tests which are part of this agreement enable rapid identification of Staphylococcus aureus, Candida albicans, and Enterococcus faecalis and other species from positive blood cultures.
We are currently looking into designing small molecules such as specific peptide nucleic acids, which are stable and can be easily delivered to block the cancer-driven RNA editing process, said Prof Tan, who is also from the Duke-NUS Medical School and Genome Institute of Singapore (GIS).
This has been an ongoing challenge of molecular biologists, with few approaches emerging, such as peptide nucleic acids (PNA), triplex forming oligonucleotides (TFO), minor groove binding polyamides, and engineered proteins.