penicillamine /pen·i·cil·la·mine/ (pen″ĭ-sil´ah-mēn) a degradation product of penicillin that chelates certain heavy metals and also binds cystine and promotes its excretion; used in the treatment of Wilson's disease, cystinuria, recurrent cystine renal calculi, and rheumatoid arthritis.
Penicillamine (Cuprimine, Depen)
penicillamine
penicillamine [pen″ĭ-sil´ah-mēn]
penicillamine
pen·i·cil·la·mine (p n  -sl  -m n)n. A degradation product of penicillin that is used as a chelating agent and in the treatment of rheumatoid arthritis and copper poisoning. |
Penicillamine (Cuprimine, Depen)
A drug used to treat medical problems (such as excess copper in the body and rheumatoid arthritis) and to prevent kidney stones. It is also sometimes prescribed to remove excess lead from the body.
Mentioned in: Lead Poisoning
penicillamine
[pen′isil′əmēn]
a chelating agent.
indications It is prescribed for the treatment of Wilson's disease and cystinuria and can be prescribed to bind with and remove heavy metals from the blood when there is poisoning resulting from metals such as copper, lead, mercury, arsenic, and gold (succimer is preferred for lead and mercury toxicity). It is also prescribed as a palliative in the treatment of systemic sclerosis (scleroderma) and rheumatoid arthritis when other medications have failed.
contraindications Known hypersensitivity to this drug or penicillamine-related aplastic anemia prohibits its use. It is not given to patients who are pregnant or who have kidney dysfunction.
adverse effects Among the more serious adverse effects are fever, rashes, and blood dyscrasias. Severe bone marrow depression and immune disorders have been associated with long-term use of this drug. d-penicillamine is less toxic than the l form, and much of the reported toxicity is caused by the use of the l or dl form.
penicillamine [pen″ĭ-sil´ah-mēn]
a degradation product of penicillin that chelates certain heavy metals; used orally to reduce the blood copper level in Wilson's disease and to promote excretion of cystine in patients with cystinuria or recurrent cystine renal calculus formation, by helping to solubilize cystine. It is also used as a disease-modifying antirheumatic drug in treatment of refractory rheumatoid arthritis.
penicillamine, d-penicillamine
a product of penicillin which chelates copper and other metals; used in the treatment of copper accumulation associated with chronic hepatitis, copper-associated hepatopathy of Bedlington terriers, and lead poisoning.
penicillamine
Metabolic disease A drug that removes copper, lead, mercury, and other metals from the body, which inhibit angiogenesis in brain tumors
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