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Etymology: Karel Pelger, Dutch physician, 1885-1931; G.J. Huët, Dutch physician, 1879-1970; Gk, anomalia, irregular
an inherited disorder characterized by granulocytes with unusually coarse nuclear material and dumbbell-shaped or peanut-shaped nuclei. Normal nuclear segmentation does not occur, but there are no clinical consequences.
Pelger-Huët anomaly(pel″gĕr hū′ĕt)
[Karel Pelger, Dutch physician, 1885–1931; Gauthier Jean Huët, Dutch physician, 1879–1970],
A benign autosomal dominant disorder of neutrophil maturation, in which granulocytes form with rodlike, dumbbell, peanut-shaped, and spectacle-like nuclei. The chromatin of the nuclei is unusually coarse. Despite their unusual shape, the oddly formed cells function normally. An anomaly in white blood cell formation called Pseudo-PHA or acquired PHA appears structurally similar to PHA and occurs in myelodysplasia and some leukemias.
an anomaly, probably inherited, of neutrophils and eosinophils in which there is hyposegmentation of the nuclei. Seen rarely in dogs and cats with no clinical significance.
pseudo-Pelger-Huët anomaly-H. a
a transient hyposegmentation in neutrophils and eosinophils, usually from unknown causes. May be mistaken as the congenital anomaly.