PARK2

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Related to Parkin: Parkinson's disease

PARK2

A gene on chromosome 6q25.2-q27 that encodes a protein that functions within a multiprotein E3 ubiquitin ligase complex, catalysing the covalent attachment of ubiquitin moieties onto substrate proteins—e.g., BCL2, SYT11, CCNE1, GPR37, STUB1, SEPT5, ZNF746 and AIMP2. It also participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating polyubiquitination of misfolded proteins. PARK2 may play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis; it may have tumour suppressor activity.
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Appeal Judge, Sir Brian Leveson, said the 23 years Parkin must serve before even applying for release was "not unduly lenient".
Jurors heard Parkin, 42, told police: "I'm addicted.
After a blind taste test, reporters Andrew Robinson and Susie Beever were in agreement which parkin was the best.
Parkin levelled from close range seven minutes later after the Cheltenham defence failed to deal with a corner.
358 million worth of budget for the next year for the Parkin Properties of Wallbridge, situated north of Capreol.
She told him her age -but it didn't stop Parkin committing the sickening crimes.
Therefore, on the basis of previous findings, we presumed that parkin and Drp1 would exert neuroprotective effect on cerebral ischemia/reperfusion that occurred in stroke.
He was eventually shipped out on loan initially in 2011 when a deeply-unimpressed Malky Mackay took charge, but Parkin, now 33, has not forgotten where the net is.
Jon > But in the latest of a series of interviews with former Bluebirds players by Steve Davies-Evans, the man behind the fans' podcast site, Built on Sloper Road, Parkin has lifted the lid on Cardiff days.
Ming Guo, the study team leader, associate professor of neurology and pharmacology and a practicing neurologist at UCLA was one of two groups worldwide that first reported in 2006 in the journal Nature that two of these genes, PTEN-induced putative kinase 1 (PINK1) and PARKIN, act together to maintain the health of mitochondria - the power house of the cell that is important in maintaining brain health.
Parkin, Archives, and Photography: Reflections on the Practice and Presentation of Modern Architecture