PARK2

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Related to Parkin: Parkinson's disease

PARK2

A gene on chromosome 6q25.2-q27 that encodes a protein that functions within a multiprotein E3 ubiquitin ligase complex, catalysing the covalent attachment of ubiquitin moieties onto substrate proteins—e.g., BCL2, SYT11, CCNE1, GPR37, STUB1, SEPT5, ZNF746 and AIMP2. It also participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating polyubiquitination of misfolded proteins. PARK2 may play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis; it may have tumour suppressor activity.
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Parkin is in talks with majority shareholder and chairman Massimo Cellino about taking over control of Leeds from the Italian.
Parkin denied making the threat, and claimed he had been simply telling the men what had happened two years ago, when he had admitted trying to set fire to the mosque.
Parkin is negotiating a buyout at Elland Road with majority owner Massimo Cellino and has identified Moyes as the manager for his new regime.
It is believed that Leeds fan Parkin has sent in lawyers to check the details before completing a deal to buy out the Italian.
Parkin, of Burgh Mill Gardens in Dewsbury, then took it with him after he went to confront his sister's boyfriend as he disliked the fact that he had moved into his family's home.
He was eventually shipped out on loan initially in 2011 when a deeply-unimpressed Malky Mackay took charge, but Parkin, now 33, has not forgotten where the net is.
Jon > But in the latest of a series of interviews with former Bluebirds players by Steve Davies-Evans, the man behind the fans' podcast site, Built on Sloper Road, Parkin has lifted the lid on Cardiff days.
These parkin assets originated at now-defunct biotech Elan Pharmaceuticals, where Imago leaders worked on another target: c-Jun N-terminal kinase, or JNK.
The recipe is for a Parkin cake which the blog describes as a ginger cake that's warming and sweet.
Parkin and Whitfield worked together early on to keep with Leese but the latter was held up by a back marker on lap 11, allowing the front two drivers to break away.
Ming Guo, the study team leader, associate professor of neurology and pharmacology and a practicing neurologist at UCLA was one of two groups worldwide that first reported in 2006 in the journal Nature that two of these genes, PTEN-induced putative kinase 1 (PINK1) and PARKIN, act together to maintain the health of mitochondria - the power house of the cell that is important in maintaining brain health.
Middlesbrough FC supporters Julie Phillips, 50, and Gemma Parkin, 18, admitted tearing up a book, but told magistrates they did not know it was Islam's holy text.