paraneoplastic syndromes

paraneoplastic syndromes

[-nē′əplas′tik]
Etymology: Gk, para + neos, new, plassein, to mold, syn, together, dromos, course
the indirect effects of a tumor that occur distant to the tumor or metastatic site. They may result from the production of active proteins, polypeptides, or inactive hormones by the tumor.

paraneoplastic syndrome

Oncology A co-morbid condition due to the indirect–remote or 'biologic' effects of malignancy, which may be the first sign of a neoplasm or its recurrence; PSs occur in > 15% of CAs, are caused by hormones, growth factors, biological response modifiers, and other as-yet unidentified factors, and may regress with treatment of the primary tumor. See Ectopic hormone.
Paraneoplastic syndromes
GI tract, eg anorexia, vomiting, protein-losing enteropathy, liver disease
Hematologic, eg leukemoid reaction, reactive eosinophilia, peripheral 'cytoses or 'cytopenias, hemolysis, DIC, thromboembolism, thrombophlebitis migrans
Hormonal effects
Metabolic disease, eg lactic acidosis, hypertrophic pulmonary osteoarthropathy, hyperamylasemia, hyperlipidemia
Neuromuscular, eg peripheral neuropathy, myopathy, CNS, spinal cord degeneration, inflammation
Renal, eg nephrotic syndrome, uric acid nephropathy
Skin, eg bullous mucocutaneous lesions, acquired ichthyosis, acanthosis nigricans, dermatomyositis
Others, eg callus formation, hypertension, and amyloidosis

paraneoplastic syndromes

(pă-ră-nēō-plăs′-tĭk)
Indirect effects of cancers, such as metabolic disturbances or hormonal excesses produced by chemicals released by tumor cells. Tumors such as small-cell carcinoma of the lung, hypernephroma, and neuroendocrine cancers are often responsible.

paraneoplastic syndromes

Syndromes caused by the secretion into the blood of the products of cancers, usually polypeptide hormones, which affect parts remote from the tumours. Thus, lung cancers can secrete ANTIDIURETIC HORMONE or ACTH and cause confusing effects.
References in periodicals archive ?
Before the start of the EIP Encephalitis Project, it was well recognized that paraneoplastic syndromes could cause limbic encephalitis, albeit infrequently.
Since 2010, the Interlaken Leadership Awards has awarded over $5 million in grants and/or study drug for research studying Ig therapy in areas such as neuromyelitis optica (NMO), Duchenne muscular dystrophy (DMD), complex regional pain syndrome (CRPS), paraneoplastic syndromes, autoimmune peripheral neuropathies, and Guillain-Barre syndrome (GBS).
Initial evaluation of the patient with lung cancer: symptoms, signs, laboratory tests, and paraneoplastic syndromes.
One theory is that DM and ADM represent paraneoplastic syndromes, where factors from a pre-existing tumour trigger an inflammatory or immune-mediated response leading to cutaneous manifestations, with or without the myopathy.
Rheumatic syndromes associated with paraneoplastic syndromes include rheumatoid arthritis, Sjogren's syndrome, systemic sclerosis, temporal arteritis, carcinoma polyarthritis, dermatomyositis, lupus erythematosus, and vasculitis.
Paraneoplastic syndromes include a variety of disorders that affect the neurologic, endocrine, mucocutaneous, hematologic, and other systems as a result of neoplastic disease.
Besides the common eosinophilia occurring during allergic reactions and parasitic manifestations, it is likely that some patients with solid tumors will develop eosinophilia as one of the paraneoplastic syndromes, which is mediated by the actions of cytokines, especially when treatment-related tumor necrosis and/or metastasis into bone marrow have also been confirmed.
3), (4) Unlike thymomas, thymic carcinomas rarely cause paraneoplastic syndromes.
On the other hand, many patients with RCC present with or subsequently develop paraneoplastic syndromes including anemia, fever, hypercalcemia, erythrocytosis, thrombocytosis, and AA amyloidosis.
To date, the Interlaken Leadership Awards has provided $2 million in grants to research studying Ig therapy in areas such as neuromyelitis optica (NMO), Duchenne muscular dystrophy (DMD), complex regional pain syndrome (CRPS), acute ischemic stroke, paraneoplastic syndromes, and autoimmune peripheral neuropathies.
5), (6) Paraneoplastic syndromes are of a neurologic nature (confusion, sensory, or motor deficits) and can include peripheral neuropathy, Lambert-Eaton syndrome (myasthenia gravis), Cushing disease, and limbic encephalitis.